{"doi":"10.1073/pnas.1009346107","title":"Development of the malaria parasite in the skin of the mammalian host","abstract":"<jats:p>\n                    The first step of\n                    <jats:italic>Plasmodium</jats:italic>\n                    development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage that invades erythrocytes and initiates the disease. The current view is that, in mammals, this stage conversion occurs only inside hepatocytes. Here, we document the transformation of sporozoites of rodent-infecting\n                    <jats:italic>Plasmodium</jats:italic>\n                    into merozoites in the skin of mice. After mosquito bite, ∼50% of the parasites remain in the skin, and at 24 h ∼10% are developing in the epidermis and the dermis, as well as in the immunoprivileged hair follicles where they can survive for weeks. The parasite developmental pathway in skin cells, although frequently abortive, leads to the generation of merozoites that are infective to erythrocytes and are released via merosomes, as typically observed in the liver. Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2010,"id":616000,"datarank":0.7525919755222388,"base_score":5.017279836814924,"endowment":5.017279836814924,"self_citation_contribution":0.7525919755222388,"citation_network_contribution":0.0,"self_endowment_contribution":0.7525919755222388,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":150,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":489185,"name":"Joana Tavares","orcid":"0000-0001-7083-6266","position":1,"is_corresponding":false},{"id":930974,"name":"Sabine Thiberge","orcid":"0000-0001-5507-0602","position":2,"is_corresponding":false},{"id":1040324,"name":"Florence Bernex","orcid":"0000-0003-0366-4315","position":3,"is_corresponding":false},{"id":875134,"name":"Tomoko Ishino","orcid":"0000-0003-2466-711X","position":4,"is_corresponding":false},{"id":1587982,"name":"Genevieve Milon","orcid":null,"position":5,"is_corresponding":false},{"id":1587983,"name":"Blandine Franke–Fayard","orcid":null,"position":6,"is_corresponding":false},{"id":693436,"name":"Chris J. Janse","orcid":"0000-0002-6410-6205","position":7,"is_corresponding":false},{"id":1522873,"name":"Robert Ménard","orcid":null,"position":8,"is_corresponding":false},{"id":1587984,"name":"Rogerio Amino","orcid":null,"position":9,"is_corresponding":false},{"id":1587981,"name":"Pascale Gueirard","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Development of the malaria parasite in the skin of the mammalian host","abstract":"<jats:p>\n                    The first step of\n                    <jats:italic>Plasmodium</jats:italic>\n                    development in vertebrates is the transformation of the sporozoite, the parasite stage injected by the mosquito in the skin, into merozoites, the stage that invades erythrocytes and initiates the disease. The current view is that, in mammals, this stage conversion occurs only inside hepatocytes. Here, we document the transformation of sporozoites of rodent-infecting\n                    <jats:italic>Plasmodium</jats:italic>\n                    into merozoites in the skin of mice. After mosquito bite, ∼50% of the parasites remain in the skin, and at 24 h ∼10% are developing in the epidermis and the dermis, as well as in the immunoprivileged hair follicles where they can survive for weeks. The parasite developmental pathway in skin cells, although frequently abortive, leads to the generation of merozoites that are infective to erythrocytes and are released via merosomes, as typically observed in the liver. Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20921402","pmcid":"PMC2972976","openalex_id":null,"authors":[],"funders":[{"funder_name":"Fundação para a Ciência e a Tecnologia, I.P.","grant_id":"PTDC/CCI-BIO/29266/2017","title":"Deep Drug Discovery and Deployment"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":2,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1009346107","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1009346107","host_type":""},{"url":"http://www.pnas.org/content/107/43/18640.full.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/20921402","host_type":""},{"url":"https://pasteur.hal.science/pasteur-02425487v1","host_type":""},{"url":"https://dx.doi.org/10.1073/pnas.1009346107","host_type":""},{"url":"https://hdl.handle.net/1887/111670","host_type":""},{"url":"https://doi.org/https://doi.org/10.1073/pnas.1009346107","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Epidermis","Hair Follicle","Skin","Dermis","Animals","Mice, Inbred C57BL","Mice","Anopheles","Plasmodium berghei","Plasmodium yoelii","Sporozoites","Malaria","Green Fluorescent Proteins","Merozoites","Host-Parasite Interactions","Mice, Hairless"],"keywords":["MESH: Plasmodium berghei/genetics","Plasmodium","Plasmodium berghei","Green Fluorescent Proteins","MESH: Plasmodium yoelii/pathogenicity","Hairless","Inbred C57BL","MESH: Host-Parasite Interactions","Host-Parasite Interactions","Mice","MESH: Anopheles/parasitology","MESH: Hair Follicle/parasitology","MESH: Dermis/parasitology","schizogony","Anopheles","Animals","MESH: Animals","MESH: Mice","[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology","MESH: Malaria/parasitology","Skin","Mice, Hairless","MESH: Malaria/transmission","MESH: Merozoites/growth & development","660","Merozoites","MESH: Plasmodium berghei/growth & development*","MESH: Green Fluorescent Proteins/genetics","MESH: Plasmodium yoelii/growth & development*","Dermis","Plasmodium yoelii","MESH: Plasmodium yoelii/genetics","Malaria","Mice, Inbred C57BL","MESH: Epidermis/parasitology","[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology","MESH: Sporozoites/growth & development","Sporozoites","MESH: Skin/parasitology*","MESH: Plasmodium berghei/pathogenicity","intravital imaging Plasmodium schizogony plasmodium-berghei vaccine development sporozoites liver hepatocyte falciparum infection mosquito protein blimp1","intravital imaging","Epidermis","Hair Follicle"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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