{"doi":"10.1073/pnas.0900060106","title":"Cytokinin regulates root meristem activity via modulation of the polar auxin transport","abstract":"<jats:p>Plant development is governed by signaling molecules called phytohormones. Typically, in certain developmental processes more than 1 hormone is implicated and, thus, coordination of their overlapping activities is crucial for correct plant development. However, molecular mechanisms underlying the hormonal crosstalk are only poorly understood. Multiple hormones including cytokinin and auxin have been implicated in the regulation of root development. Here we dissect the roles of cytokinin in modulating growth of the primary root. We show that cytokinin effect on root elongation occurs through ethylene signaling whereas cytokinin effect on the root meristem size involves ethylene-independent modulation of transport-dependent asymmetric auxin distribution. Exogenous or endogenous modification of cytokinin levels and cytokinin signaling lead to specific changes in transcription of several auxin efflux carrier genes from the PIN family having a direct impact on auxin efflux from cultured cells and on auxin distribution in the root apex. We propose a novel model for cytokinin action in regulating root growth: Cytokinin influences cell-to-cell auxin transport by modification of expression of several auxin transport components and thus modulates auxin distribution important for regulation of activity and size of the root meristem.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2009,"id":24380,"datarank":10.483788910400218,"base_score":6.021023349349527,"endowment":6.021023349349527,"self_citation_contribution":0.9031535024024291,"citation_network_contribution":9.58063540799779,"self_endowment_contribution":0.9031535024024291,"citer_contribution":9.58063540799779,"corpus_percentile":null,"corpus_rank":null,"citation_count":411,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":146464,"name":"Mária Šimášková","orcid":null,"position":1,"is_corresponding":false},{"id":146465,"name":"Jerome Duclercq","orcid":null,"position":2,"is_corresponding":false},{"id":146466,"name":"Jan Petrášek","orcid":null,"position":3,"is_corresponding":false},{"id":146467,"name":"Eva Zažímalová","orcid":null,"position":4,"is_corresponding":false},{"id":146468,"name":"Sibu Simon","orcid":null,"position":5,"is_corresponding":false},{"id":146469,"name":"Jiří Friml","orcid":null,"position":6,"is_corresponding":false},{"id":146470,"name":"Marc C. 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Van Montagu","orcid":null,"position":7,"is_corresponding":false},{"id":146472,"name":"Eva Benková","orcid":null,"position":8,"is_corresponding":false},{"id":146463,"name":"Kamil Růžička","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.021023349349527,"endowment":6.021023349349527,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19246387","pmcid":"PMC2657394","openalex_id":"https://openalex.org/W2071084402","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"207362","title":"Hormonal cross-talk in plant organogenesis"}],"total_grants":1,"fwci":37.0845,"citation_percentile":0.9984659,"influential_citations":15,"citation_trend":[{"year":2012,"count":30},{"year":2013,"count":31},{"year":2014,"count":31},{"year":2015,"count":31},{"year":2016,"count":26},{"year":2017,"count":29},{"year":2018,"count":18},{"year":2019,"count":17},{"year":2020,"count":22},{"year":2021,"count":26},{"year":2022,"count":26},{"year":2023,"count":19},{"year":2024,"count":20},{"year":2025,"count":21},{"year":2026,"count":6}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/106/11/4284.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/106/11/4284.full.pdf","host_type":"BRONZE"},{"url":"https://www.pnas.org/content/pnas/106/11/4284.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.0900060106","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.0900060106","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19246387","host_type":"repository"},{"url":"http://hdl.handle.net/1854/LU-592986","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657394","host_type":"repository"},{"url":"http://dx.doi.org/10.1073/pnas.0900060106","host_type":""},{"url":"https://dx.doi.org/10.1073/pnas.0900060106","host_type":""}],"fields_of_study":["Plant Molecular Biology Research","Plant Reproductive Biology","Polysaccharides and Plant Cell Walls","Medicine","Biology","Environmental Science","0301 basic medicine","0303 health sciences","03 medical and health sciences","Biological Transport","Cytokinins","Indoleacetic Acids","Meristem","Plant Growth Regulators","Plant Physiological Phenomena","Plant Roots"],"mesh_terms":["Biological Transport","Cytokinins","Indoleacetic Acids","Plant Growth Regulators","Plant Roots","Meristem","Plant Physiological Phenomena"],"keywords":["Auxin","Cytokinin","Meristem","Polar auxin transport","Cell biology","Crosstalk","Biology","Plant hormone","Lateral root","Arabidopsis","Biochemistry","Gene","Mutant","Cytokinins","Indoleacetic Acids","Plant Growth Regulators","Biological Transport","Plant Roots","Plant Physiological Phenomena"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T22:17:00.585479Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}