{"doi":"10.1073/pnas.0705832104","title":"A unique Extradenticle recruitment mode in the\n                    <i>Drosophila</i>\n                    Hox protein Ultrabithorax","abstract":"<jats:p>\n                    Hox transcription factors are essential for shaping body morphology in development and evolution. The control of Hox protein activity in part arises from interaction with the PBC class of partners, pre-B cell transcription factor (Pbx) proteins in vertebrates and Extradenticle (Exd) in\n                    <jats:italic>Drosophila</jats:italic>\n                    . Characterized interactions occur through a single mode, involving a short hexapeptide motif in the Hox protein. This apparent uniqueness in Hox–PBC interaction provides little mechanistic insight in how the same cofactors endow Hox proteins with specific and diverse activities. Here, we identify in the\n                    <jats:italic>Drosophila</jats:italic>\n                    Ultrabithorax (Ubx) protein a short motif responsible for an alternative mode of Exd recruitment. Together with previous reports, this finding highlights that the Hox protein Ubx has multiple ways to interact with the Exd cofactor and suggests that flexibility in Hox–PBC contacts contributes to specify and diversify Hox protein function.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2007,"id":40450,"datarank":2.8585107447759173,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":2.1921130563023694,"self_endowment_contribution":0.6663976884735476,"citer_contribution":2.1921130563023694,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":56,"citers_with_citation_signal":50,"citers_with_endowment":50,"datacite_reuse_total":4,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196502,"name":"Mehdi Saadaoui","orcid":null,"position":1,"is_corresponding":false},{"id":196503,"name":"Nagraj Sambrani","orcid":null,"position":2,"is_corresponding":false},{"id":196504,"name":"Bruno Hudry","orcid":null,"position":3,"is_corresponding":false},{"id":196484,"name":"Jacques Pradel","orcid":null,"position":4,"is_corresponding":false},{"id":196505,"name":"Markus Affolter","orcid":null,"position":5,"is_corresponding":false},{"id":196485,"name":"Yacine Graba","orcid":null,"position":6,"is_corresponding":false},{"id":116402,"name":"Samir Merabet","orcid":"0000-0001-7629-703X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.442651256490317,"endowment":4.442651256490317,"datacite_reuse_total":4,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17942685","pmcid":"PMC2040397","openalex_id":"https://openalex.org/W2143495231","authors":[],"funders":[],"total_grants":0,"fwci":2.961,"citation_percentile":0.91589039,"influential_citations":4,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":4},{"year":2017,"count":4},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":10},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2040397","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc2040397?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2040397","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.0705832104","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.0705832104","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17942685","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Microtubule and mitosis dynamics","Hippo pathway signaling and YAP/TAZ","Biology","Medicine","Amino Acid Motifs","Amino Acid Sequence","Animals","Antennapedia Homeodomain Protein","Drosophila Proteins","Drosophila melanogaster","Embryo, Nonmammalian","Gene Expression Regulation, Developmental","Homeodomain Proteins","Models, Biological","Molecular Sequence Data","Protein Transport","Regulatory Sequences, Nucleic Acid","Repressor Proteins","Sequence Deletion","Transcription Factors"],"mesh_terms":["Amino Acid Sequence","Animals","Drosophila melanogaster","Embryo, Nonmammalian","Models, Biological","Molecular Sequence Data","Regulatory Sequences, Nucleic Acid","Repressor Proteins","Transcription Factors","Sequence Deletion","Homeodomain Proteins","Gene Expression Regulation, Developmental","Amino Acid Motifs","Protein Transport","Drosophila Proteins","Antennapedia Homeodomain Protein"],"keywords":["Ultrabithorax","Hox gene","Biology","Drosophila (subgenus)","Genetics","Drosophila melanogaster","Cell biology","Gene","Transcription factor"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.20388427.v1","title":"Additional file 1 of Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20388427","title":"Additional file 1 of Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20388430","title":"Additional file 2 of Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.20388430.v1","title":"Additional file 2 of Characterizing Hox genes in mayflies (Ephemeroptera), with Hexagenia limbata as a new mayfly model","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T06:13:29.197761Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}