{"doi":"10.1073/pnas.051609998","title":"Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the\n                    <i>Caulobacter</i>\n                    cell cycle","abstract":"<jats:p>\n                    We present evidence that a bacterial signal transduction cascade\n that couples morphogenesis with cell cycle progression is regulated by\n dynamic localization of its components. Previous studies have\n implicated two histidine kinases, DivJ and PleC, and the response\n regulator, DivK, in the regulation of morphogenesis in the dimorphic\n bacterium\n                    <jats:italic>Caulobacter crescentus</jats:italic>\n                    . Here, we show that the\n cytoplasmic response regulator, DivK, exhibits a dynamic, cyclical\n localization that culminates in asymmetric distribution of DivK within\n the two cell types that are characteristic of the\n                    <jats:italic>Caulobacter</jats:italic>\n                    cell cycle; DivK is dispersed throughout the\n cytoplasm of the progeny swarmer cell and is localized to the pole of\n the stalked cell. The membrane-bound DivJ and PleC histidine kinases,\n which are asymmetrically localized at the opposite poles of the\n predivisional cell, control the temporal and spatial localization of\n DivK. DivJ mediates DivK targeting to the poles whereas PleC controls\n its release from one of the poles at times and places that are\n consistent with the activities and location of DivJ and PleC in the\n late predivisional cell. Thus, dynamic changes in subcellular location\n of multiple components of a signal transduction cascade may constitute\n a novel mode of prokaryotic regulation to generate and maintain\n cellular asymmetry.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2001,"id":684549,"datarank":0.7050720548688626,"base_score":4.700480365792417,"endowment":4.700480365792417,"self_citation_contribution":0.7050720548688626,"citation_network_contribution":0.0,"self_endowment_contribution":0.7050720548688626,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":109,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1788382,"name":"Dean Hung","orcid":null,"position":1,"is_corresponding":false},{"id":270552,"name":"Lucy Shapiro","orcid":"0000-0002-0445-067X","position":2,"is_corresponding":false},{"id":1788381,"name":"Christine Jacobs","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the\n                    <i>Caulobacter</i>\n                    cell cycle","abstract":"<jats:p>\n                    We present evidence that a bacterial signal transduction cascade\n that couples morphogenesis with cell cycle progression is regulated by\n dynamic localization of its components. Previous studies have\n implicated two histidine kinases, DivJ and PleC, and the response\n regulator, DivK, in the regulation of morphogenesis in the dimorphic\n bacterium\n                    <jats:italic>Caulobacter crescentus</jats:italic>\n                    . Here, we show that the\n cytoplasmic response regulator, DivK, exhibits a dynamic, cyclical\n localization that culminates in asymmetric distribution of DivK within\n the two cell types that are characteristic of the\n                    <jats:italic>Caulobacter</jats:italic>\n                    cell cycle; DivK is dispersed throughout the\n cytoplasm of the progeny swarmer cell and is localized to the pole of\n the stalked cell. The membrane-bound DivJ and PleC histidine kinases,\n which are asymmetrically localized at the opposite poles of the\n predivisional cell, control the temporal and spatial localization of\n DivK. DivJ mediates DivK targeting to the poles whereas PleC controls\n its release from one of the poles at times and places that are\n consistent with the activities and location of DivJ and PleC in the\n late predivisional cell. Thus, dynamic changes in subcellular location\n of multiple components of a signal transduction cascade may constitute\n a novel mode of prokaryotic regulation to generate and maintain\n cellular asymmetry.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.700480365792417,"endowment":4.700480365792417,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11274434","pmcid":"PMC31185","openalex_id":"https://openalex.org/W2037447864","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM32506/5120 M2","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM032506","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM032506","title":null}],"total_grants":3,"fwci":5.2136,"citation_percentile":0.95826424,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":3},{"year":2014,"count":8},{"year":2015,"count":5},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":4},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":5},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/31185","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/31185","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.051609998","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.051609998","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11274434","host_type":"repository"}],"fields_of_study":["Bacterial Genetics and Biotechnology","Bacterial biofilms and quorum sensing","Genomics and Phylogenetic Studies","Bacterial Proteins","Caulobacter crescentus","Cell Cycle","Green Fluorescent Proteins","Histidine Kinase","Luminescent Proteins","Phosphorylation","Protein Kinases","Recombinant Fusion Proteins","Signal Transduction","Subcellular Fractions"],"mesh_terms":["Histidine Kinase","Bacterial Proteins","Cell Cycle","Luminescent Proteins","Phosphorylation","Protein Kinases","Recombinant Fusion Proteins","Subcellular Fractions","Signal Transduction","Caulobacter crescentus","Green Fluorescent Proteins"],"keywords":["Caulobacter crescentus","Response regulator","Cell biology","Biology","Histidine kinase","Morphogenesis","Cytoplasm","Signal transduction","Regulator","Cell cycle","Subcellular localization","Cell","Genetics","Histidine","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T14:24:31.890134Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}