{"doi":"10.1073/pnas.041614598","title":"Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate","abstract":"Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK). By phosphorylating inositol 4,5-bisphosphate, mIPMK provides an alternative biosynthesis for inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)]. mIPMK also can form the pyrophosphate disphosphoinositol tetrakisphosphate (PP-InsP(4)) from InsP(5). Additionally, mIPMK forms InsP(4) from Ins(1,4,5)P(3) and InsP(5) from Ins(1,3,4,5)P(4).","journal":"Proceedings of the National Academy of Sciences","year":2001,"id":9542,"datarank":4.502245435070514,"base_score":4.700480365792417,"endowment":4.700480365792417,"self_citation_contribution":0.7050720548688626,"citation_network_contribution":3.7971733802016514,"self_endowment_contribution":0.7050720548688626,"citer_contribution":3.7971733802016514,"corpus_percentile":null,"corpus_rank":null,"citation_count":109,"citer_count":85,"citers_with_citation_signal":71,"citers_with_endowment":71,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0455,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2001-02-13","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":79949,"name":"Eiichiro Nagata","orcid":"0000-0001-6902-8309","position":1,"is_corresponding":false},{"id":79950,"name":"Hongbo R. Luo","orcid":"0000-0002-8545-0451","position":2,"is_corresponding":false},{"id":33854,"name":"Akira Sawa","orcid":"0000-0003-1401-3008","position":3,"is_corresponding":false},{"id":79951,"name":"Xiaojiang Luo","orcid":null,"position":4,"is_corresponding":false},{"id":79952,"name":"Adele M. Snowman","orcid":null,"position":5,"is_corresponding":false},{"id":79953,"name":"Solomon H. Snyder","orcid":"0000-0002-6818-7022","position":6,"is_corresponding":false},{"id":52559,"name":"Adolfo Saiardi","orcid":"0000-0002-4351-0081","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}