{"doi":"10.1073/pnas.0408729102","title":"Muscle regeneration in the prolonged absence of myostatin","abstract":"\n Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous studies in the\n mdx\n mouse model of muscular dystrophy demonstrate that inhibiting myostatin attenuates several features of dystrophic muscle. These findings have encouraged the development of human therapies to block myostatin. However, little is known of the long-term effects on muscle of myostatin blockade. To evaluate potential sequelae from the prolonged absence of myostatin, senescent myostatin null (\n mstn\n -/-\n ) mice were studied. Senescent\n mstn\n -/-\n mice continue to have normal muscle with increased mass and strength relative to controls. Muscles of senescent\n mstn\n -/-\n mice regenerate robustly from both chronic and acute injury. Early markers of regeneration are enhanced in the absence of myostatin, suggesting a mechanism for the attenuation of dystrophic features found in\n mdx\n mice lacking myostatin.\n ","journal":"Proceedings of the National Academy of Sciences","year":2005,"id":41284,"datarank":8.845316259074195,"base_score":5.220355825078325,"endowment":5.220355825078325,"self_citation_contribution":0.7830533737617489,"citation_network_contribution":8.062262885312446,"self_endowment_contribution":0.7830533737617489,"citer_contribution":8.062262885312446,"corpus_percentile":null,"corpus_rank":null,"citation_count":184,"citer_count":166,"citers_with_citation_signal":152,"citers_with_endowment":152,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":199084,"name":"Xiaosong Liu","orcid":null,"position":1,"is_corresponding":false},{"id":199085,"name":"Xiaoli Chang","orcid":null,"position":2,"is_corresponding":false},{"id":199086,"name":"Ronald E. 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Wagner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.220355825078325,"endowment":5.220355825078325,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15699335","pmcid":"PMC548322","openalex_id":"https://openalex.org/W2083409148","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"K08 NS002212","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"K08NS02212","title":null},{"funder_name":"National Institutes of Health","grant_id":"5K08NS002212-05","title":"Myostatin in Muscle Growth and Regeneration"}],"total_grants":3,"fwci":6.8258,"citation_percentile":0.97777111,"influential_citations":7,"citation_trend":[{"year":2012,"count":13},{"year":2013,"count":6},{"year":2014,"count":8},{"year":2015,"count":13},{"year":2016,"count":9},{"year":2017,"count":5},{"year":2018,"count":9},{"year":2019,"count":5},{"year":2020,"count":6},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/548322","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc548322?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/548322","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.0408729102","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.0408729102","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15699335","host_type":"repository"},{"url":"https://dx.doi.org/10.1073/pnas.0408729102","host_type":""}],"fields_of_study":["Muscle Physiology and Disorders","Tissue Engineering and Regenerative Medicine","Genetics, Aging, and Longevity in Model Organisms","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Aging","Animals","Cattle","Cell Differentiation","Cell Proliferation","Humans","Mice","Mice, Inbred C57BL","Mice, Knockout","Muscle, Skeletal","Myostatin","Regeneration","Transforming Growth Factor beta"],"mesh_terms":["Aging","Animals","Cattle","Cell Differentiation","Humans","Mice, Inbred C57BL","Regeneration","Transforming Growth Factor beta","Mice, Knockout","Muscle, Skeletal","Cell Proliferation","Mice","Myostatin"],"keywords":["Myostatin","Muscular dystrophy","Regeneration (biology)","Biology","Skeletal muscle","Duchenne muscular dystrophy","Endocrinology","Internal medicine","Myocyte","Medicine","Cell biology","Mice, Knockout","Aging","Cell Differentiation","Mice, Inbred C57BL","Mice","Transforming Growth Factor beta","Animals","Humans","Regeneration","Cattle","Muscle, Skeletal","Cell Proliferation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T23:03:43.177467Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}