{"doi":"10.1067/mai.2003.1333","title":"IL-13 receptors and signaling pathways: An evolving web","abstract":null,"journal":"Journal of Allergy and Clinical Immunology","year":2003,"id":616232,"datarank":0.9627547403904319,"base_score":6.418364935936212,"endowment":6.418364935936212,"self_citation_contribution":0.9627547403904319,"citation_network_contribution":0.0,"self_endowment_contribution":0.9627547403904319,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":612,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1588671,"name":"Gurjit K.Khurana Hershey","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"IL-13 receptors and signaling pathways: An evolving web","abstract":"IL-13 is an immunoregulatory cytokine secreted predominantly by activated T(H)2 cells. Over the past several years, it has become evident that IL-13 is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, stemming from the fact that they share a common receptor subunit, the alpha subunit of the IL-4 receptor (IL-4Ralpha). Characterization of IL-13-deficient mice, IL-4-deficient mice, and IL-4 receptor alpha-deficient (IL-4Ralpha(-/-)) mice have demonstrated nonredundant roles for IL-13. IL-13 mediates its effects by interacting with a complex receptor system comprised of IL-4Ralpha and two IL-13 binding proteins, IL-13Ralpha1 and IL-13Ralpha2. IL-13 receptors are expressed on human B cells, basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells. However, functional IL-13 receptors have not been demonstrated on human or mouse T cells. Thus unlike IL-4, IL-13 does not appear to be important in the initial differentiation of CD4 T cells into T(H)2-type cells but rather appears to be important in the effector phase of allergic inflammation. This is further supported by many in vivo observations, including that administration of IL-13 resulted in allergic inflammation, tissue-specific overexpression of IL-13 in the lungs of transgenic mice resulted in airway inflammation and mucus hypersecretion, IL-13 blockade abolished allergic inflammation independently of IL-4, and IL-13 appears to be more important than IL-4 in mucus hypersecretion. Given the importance of IL-13 as an effector molecule, regulation at the level of its receptors might be an important mechanism of modulating IL-13 responses and thus propagation of the allergic response. Accordingly, IL-13 is an attractive, novel therapeutic target for pharmacologic intervention in allergic disorders. This review will summarize the current understanding of the IL-13 receptors and signaling pathways, emphasizing recent observations.","is_dataset_classified":null,"base_score":6.418364935936212,"endowment":6.418364935936212,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12704343","pmcid":null,"openalex_id":"https://openalex.org/W2132665714","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01AI46652-01A1","title":null}],"total_grants":1,"fwci":5.9914,"citation_percentile":0.97318833,"influential_citations":0,"citation_trend":[{"year":2012,"count":26},{"year":2013,"count":43},{"year":2014,"count":21},{"year":2015,"count":32},{"year":2016,"count":30},{"year":2017,"count":26},{"year":2018,"count":16},{"year":2019,"count":28},{"year":2020,"count":38},{"year":2021,"count":26},{"year":2022,"count":41},{"year":2023,"count":29},{"year":2024,"count":30},{"year":2025,"count":20},{"year":2026,"count":8}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0091674903006973?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0091674903006973?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1067/mai.2003.1333","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12704343","host_type":"repository"}],"fields_of_study":["Toxin Mechanisms and Immunotoxins","Immune Cell Function and Interaction","IL-33, ST2, and ILC Pathways","Animals","Cytokines","Humans","Interleukin-13","Interleukin-13 Receptor alpha1 Subunit","Janus Kinase 1","Protein-Tyrosine Kinases","Receptors, Interleukin","Receptors, Interleukin-13","Receptors, Interleukin-4","STAT6 Transcription Factor","Signal Transduction","Trans-Activators","src Homology Domains"],"mesh_terms":["Animals","Humans","Protein-Tyrosine Kinases","Signal Transduction","Trans-Activators","Cytokines","Receptors, Interleukin","Interleukin-13","src Homology Domains","Receptors, Interleukin-4","STAT6 Transcription Factor","Janus Kinase 1","Receptors, Interleukin-13","Interleukin-13 Receptor alpha1 Subunit"],"keywords":["Allergic inflammation","Inflammation","Receptor","Interleukin 13","Biology","Cytokine","Cell biology","Immunology","Interleukin 4"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:20:17.645430Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}