{"doi":"10.1063/5.0276218","title":"Carotid hemodynamic effects modulated by the rotary blood pump with different working modes and enhanced external counterpulsation","abstract":"Patients with advanced heart failure have compromised baroreceptor response, which may be exacerbated by the reduced pulsatility due to the constant pump speed when implanted with the continuous flow rotary blood pumps (RBP). This may be mitigated by increasing pulsatility using the pulsatile speed modulation algorithms for RBP or using an enhanced external counterpulsation (EECP). This work quantitatively elucidated the varying hemodynamic effects of the patient-specific models of carotid artery between RBP and EECP support using computational fluid dynamics. Pressure distribution, wall shear stress (WSS), time-averaged WSS (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT) were calculated. Numerical simulation results showed that both pulsatile speed modes of RBP and EECP clearly increased pulse pressure and peak WSS compared with the constant speed mode of RBP, enhanced peak blood perfusion, and may increase the stimulation of the endothelial stretch and shear responses. Moreover, the pulsatile speed mode of RBP generated the highest TAWSS, the EECP resulted in the highest OSI value, and RRT under all the conditions was basically the same. The enhancement of pulsatility and stretch in the carotid artery could minimize the adverse effects of compromised baroreceptor response in patients with advanced heart failure.","journal":"Physics of Fluids","year":2025,"id":570377,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1475678,"name":"Li Wang","orcid":"0009-0006-0818-6008","position":1,"is_corresponding":false},{"id":1475988,"name":"Qingzhuo Chi","orcid":null,"position":2,"is_corresponding":false},{"id":1475989,"name":"Shuaizhi Zhou","orcid":null,"position":3,"is_corresponding":false},{"id":457560,"name":"Guruprasad A. Giridharan","orcid":"0000-0003-3263-9354","position":4,"is_corresponding":false},{"id":1104358,"name":"Peng Qu","orcid":"0000-0002-3368-001X","position":5,"is_corresponding":false},{"id":1475990,"name":"Tong Zhiyong","orcid":null,"position":6,"is_corresponding":false},{"id":1104359,"name":"Yu Wang","orcid":"0000-0001-6690-8810","position":7,"is_corresponding":false},{"id":10637,"name":"R. Wang","orcid":"0000-0001-9839-608X","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:57:07.857542Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}