{"doi":"10.1063/5.0260500","title":"Low-frequency Raman spectra of amyloid fibrils","abstract":"We report on how low-frequency Raman measurements can be used as a facile tool to investigate the supramolecular structure of amyloid fibrils. We investigate the low-frequency Raman spectra (<500 cm-1) of six different amyloid fibrils exhibiting parallel β-sheet structures prepared from amyloid-β1-40, amylin, amyloid-β25-35, and amylin20-29 peptides. We propose band assignments using a combination of semi-empirical tight-binding calculations and insights gleaned from previously published studies on model polypeptides in β-sheet conformations. We discuss how low-frequency Raman modes can be used to probe the interactions, packing, and ordering of strands and side chains within fibril β-sheets to gain insights into their supramolecular structures.","journal":"The Journal of Chemical Physics","year":2025,"id":539544,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1426600,"name":"Amanda Dumi","orcid":"0000-0002-2693-8537","position":1,"is_corresponding":false},{"id":1426601,"name":"Shiv Upadhyay","orcid":"0000-0002-8501-0501","position":2,"is_corresponding":false},{"id":711362,"name":"Riley J. Workman","orcid":"0009-0002-8784-9949","position":3,"is_corresponding":false},{"id":1099674,"name":"Delaney Nelson","orcid":"0000-0003-4947-5691","position":4,"is_corresponding":false},{"id":1010567,"name":"Uma Nudurupati","orcid":"0000-0003-4166-384X","position":5,"is_corresponding":false},{"id":812101,"name":"Yangguang Ou","orcid":"0000-0002-6902-3978","position":6,"is_corresponding":false},{"id":467117,"name":"David Punihaole","orcid":"0000-0002-4637-9672","position":7,"is_corresponding":false},{"id":1010566,"name":"Madeline Harper","orcid":"0009-0008-9894-1875","position":0,"is_corresponding":true}],"reference_count":125,"raw_metadata":null,"created_at":"2026-07-19T02:52:30.048313Z","pmid":"40459359","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}