{"doi":"10.1056/nejmoa2501912","title":"Encorafenib, Cetuximab, and mFOLFOX6 in <i>BRAF</i> -Mutated Colorectal Cancer","abstract":"BACKGROUND: V600E-mutated metastatic colorectal cancer, including as first-line therapy. Data on progression-free survival (the second primary end point) and an updated interim analysis of overall survival are now available. METHODS: V600E-mutated metastatic colorectal cancer to receive EC, EC+mFOLFOX6, or standard care. The two primary end points were objective response (reported previously) and progression-free survival according to blinded independent central review in the EC+mFOLFOX6 group and the standard-care group. The key secondary end point was overall survival. RESULTS: Significantly longer progression-free survival was seen with EC+mFOLFOX6 than with standard care (median, 12.8 vs. 7.1 months; hazard ratio for progression or death, 0.53; 95% confidence interval [CI], 0.41 to 0.68; P<0.001). In an interim analysis, overall survival was significantly longer with EC+mFOLFOX6 than with standard care (median, 30.3 vs. 15.1 months; hazard ratio for death, 0.49; 95% CI, 0.38 to 0.63; P<0.001). The incidence of serious adverse events during treatment was 46.1% with EC+mFOLFOX6 and 38.9% with standard care. Safety profiles were consistent with those known for each agent. CONCLUSIONS: V600E-mutated metastatic colorectal cancer. (Funded by Pfizer and others; BREAKWATER ClinicalTrials.gov number, NCT04607421.).","journal":"New England Journal of Medicine","year":2025,"id":508761,"datarank":1.9034015216857747,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":1.191661702431287,"self_endowment_contribution":0.7117398192544876,"citer_contribution":1.191661702431287,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":100,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8964,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04607421"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310797,"name":"Takayuki Yoshino","orcid":"0000-0002-0489-4756","position":1,"is_corresponding":false},{"id":1361010,"name":"Lin Shen","orcid":"0000-0003-4635-1108","position":2,"is_corresponding":false},{"id":477415,"name":"Sara Lonardi","orcid":"0000-0002-7593-8138","position":3,"is_corresponding":false},{"id":88015,"name":"Eric Van Cutsem","orcid":"0000-0002-6372-1230","position":4,"is_corresponding":false},{"id":332456,"name":"Cathy Eng","orcid":"0000-0003-2335-0612","position":5,"is_corresponding":false},{"id":1027364,"name":"Tae Won Kim","orcid":null,"position":6,"is_corresponding":false},{"id":1361011,"name":"Harpreet Wasan","orcid":"0000-0002-6268-2030","position":7,"is_corresponding":false},{"id":260048,"name":"Jayesh Desai","orcid":"0000-0003-4246-9344","position":8,"is_corresponding":false},{"id":1361012,"name":"Fortunato Ciardiello","orcid":"0000-0002-3369-4841","position":9,"is_corresponding":false},{"id":90752,"name":"Rona Yaeger","orcid":"0000-0002-7233-5454","position":10,"is_corresponding":false},{"id":678552,"name":"Tim Maughan","orcid":"0000-0002-0580-5065","position":11,"is_corresponding":false},{"id":461072,"name":"Van K. Morris","orcid":"0000-0002-4911-2252","position":12,"is_corresponding":false},{"id":1024557,"name":"Christina Wu","orcid":"0000-0002-5279-9032","position":13,"is_corresponding":false},{"id":233982,"name":"Tiziana Usari","orcid":null,"position":14,"is_corresponding":false},{"id":1362294,"name":"Robert J Laliberte","orcid":null,"position":15,"is_corresponding":false},{"id":1362295,"name":"Samuel S. Dychter","orcid":null,"position":16,"is_corresponding":false},{"id":1361013,"name":"Xiaosong Zhang","orcid":"0000-0002-0122-2356","position":17,"is_corresponding":false},{"id":35283,"name":"Josep Tabernero","orcid":"0000-0002-2495-8139","position":18,"is_corresponding":false},{"id":241627,"name":"Scott Kopetz","orcid":"0000-0001-9647-3416","position":19,"is_corresponding":false},{"id":1029419,"name":"Elena Élez","orcid":"0000-0002-9178-0246","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:47:00.188082Z","pmid":"40444708","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}