{"doi":"10.1056/nejmoa2308815","title":"Electronic Nicotine-Delivery Systems for Smoking Cessation","abstract":null,"journal":"New England Journal of Medicine","year":2024,"id":600718,"datarank":0.7206031567099886,"base_score":4.804021044733257,"endowment":4.804021044733257,"self_citation_contribution":0.7206031567099886,"citation_network_contribution":0.0,"self_endowment_contribution":0.7206031567099886,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":121,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1540125,"name":"Anna Schoeni","orcid":null,"position":1,"is_corresponding":false},{"id":1540126,"name":"Jean-Paul Humair","orcid":null,"position":2,"is_corresponding":false},{"id":1540127,"name":"Isabelle Jacot-Sadowski","orcid":null,"position":3,"is_corresponding":false},{"id":1394935,"name":"Ivan Berlin","orcid":"0000-0002-5928-5616","position":4,"is_corresponding":false},{"id":1540128,"name":"Mirah J. Stuber","orcid":null,"position":5,"is_corresponding":false},{"id":1540129,"name":"Moa Lina Haller","orcid":null,"position":6,"is_corresponding":false},{"id":1540130,"name":"Rodrigo Casagrande Tango","orcid":null,"position":7,"is_corresponding":false},{"id":638688,"name":"Anja Frei","orcid":"0000-0002-7134-1000","position":8,"is_corresponding":false},{"id":1540131,"name":"Alexandra Strassmann","orcid":null,"position":9,"is_corresponding":false},{"id":933372,"name":"Philip Bruggmann","orcid":null,"position":10,"is_corresponding":false},{"id":1540133,"name":"Florent Baty","orcid":null,"position":11,"is_corresponding":false},{"id":1540134,"name":"Martin Brutsche","orcid":null,"position":12,"is_corresponding":false},{"id":422149,"name":"Kali Tal","orcid":"0000-0003-2454-2560","position":13,"is_corresponding":false},{"id":1283168,"name":"Stéphanie Baggio","orcid":"0000-0002-5347-5937","position":14,"is_corresponding":false},{"id":422147,"name":"Julian Jakob","orcid":"0000-0001-8429-3231","position":15,"is_corresponding":false},{"id":1540137,"name":"Nicolas Sambiagio","orcid":null,"position":16,"is_corresponding":false},{"id":132362,"name":"Nancy B. Hopf","orcid":null,"position":17,"is_corresponding":false},{"id":481656,"name":"Martin Feller","orcid":"0000-0003-2519-836X","position":18,"is_corresponding":false},{"id":481657,"name":"Nicolas Rodondi","orcid":"0000-0001-9083-6896","position":19,"is_corresponding":false},{"id":1540138,"name":"Aurélie Berthet","orcid":"0000-0002-8625-5156","position":20,"is_corresponding":false},{"id":422150,"name":"Reto Auer","orcid":"0000-0003-4222-4849","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Electronic Nicotine-Delivery Systems for Smoking Cessation","abstract":"BACKGROUND: Electronic nicotine-delivery systems - also called e-cigarettes - are used by some tobacco smokers to assist with quitting. Evidence regarding the efficacy and safety of these systems is needed. METHODS: In this open-label, controlled trial, we randomly assigned adults who were smoking at least five tobacco cigarettes per day and who wanted to set a quit date to an intervention group, which received free e-cigarettes and e-liquids, standard-of-care smoking-cessation counseling, and optional (not free) nicotine-replacement therapy, or to a control group, which received standard counseling and a voucher, which they could use for any purpose, including nicotine-replacement therapy. The primary outcome was biochemically validated, continuous abstinence from smoking at 6 months. Secondary outcomes included participant-reported abstinence from tobacco and from any nicotine (including smoking, e-cigarettes, and nicotine-replacement therapy) at 6 months, respiratory symptoms, and serious adverse events. RESULTS: A total of 1246 participants underwent randomization; 622 participants were assigned to the intervention group, and 624 to the control group. The percentage of participants with validated continuous abstinence from tobacco smoking was 28.9% in the intervention group and 16.3% in the control group (relative risk, 1.77; 95% confidence interval, 1.43 to 2.20). The percentage of participants who abstained from smoking in the 7 days before the 6-month visit was 59.6% in the intervention group and 38.5% in the control group, but the percentage who abstained from any nicotine use was 20.1% in the intervention group and 33.7% in the control group. Serious adverse events occurred in 25 participants (4.0%) in the intervention group and in 31 (5.0%) in the control group; adverse events occurred in 272 participants (43.7%) and 229 participants (36.7%), respectively. CONCLUSIONS: The addition of e-cigarettes to standard smoking-cessation counseling resulted in greater abstinence from tobacco use among smokers than smoking-cessation counseling alone. 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