{"doi":"10.1056/nejmoa2104226","title":"Higher-Dose Primaquine to Prevent Relapse of <i>Plasmodium vivax</i> Malaria","abstract":"BACKGROUND: malaria is primaquine at a total dose of 3.5 mg per kilogram of body weight, despite evidence of only moderate efficacy. METHODS: monoinfection. All the patients received directly observed chloroquine for 3 days (total dose, 25 mg per kilogram). Group 1 received a total primaquine dose of 3.5 mg per kilogram (0.5 mg per kilogram per day) over 7 days with unobserved administration; group 2 received the same regimen as group 1 but with observed administration; and group 3 received a total primaquine dose of 7.0 mg per kilogram over 14 days (also 0.5 mg per kilogram per day) with observed administration. We monitored the patients for 168 days. RESULTS: recurrences were observed: 2 in group 1 and 1 in group 2. By day 168, a total of 70 recurrences had occurred: 24 in group 1, 34 in group 2, and 12 in group 3. No serious adverse events were noted. On day 168, the percentage of patients without recurrence was 58% (95% confidence interval [CI], 44 to 70) in group 1, 59% (95% CI, 47 to 69) in group 2, and 86% (95% CI, 76 to 92) in group 3. Survival analysis showed a difference in the day 168 recurrence-free percentage of 27 percentage points (97.5% CI, 10 to 44; P<0.001) between group 1 and group 3 and a difference of 27 percentage points (97.5% CI, 12 to 42; P<0.001) between group 2 and group 3. CONCLUSIONS: malaria than a total dose of 3.5 mg per kilogram through day 168. (Supported by the U.S. Agency for International Development; ClinicalTrials.gov number, NCT03610399.).","journal":"New England Journal of Medicine","year":2022,"id":246154,"datarank":1.9264286579817713,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":1.3622486406277368,"self_endowment_contribution":0.5641800173540344,"citer_contribution":1.3622486406277368,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":36,"citers_with_citation_signal":24,"citers_with_endowment":24,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03610399"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":882703,"name":"Suiane C. Negreiros","orcid":null,"position":1,"is_corresponding":false},{"id":519508,"name":"Sarah-Blythe Ballard","orcid":"0000-0003-3581-5771","position":2,"is_corresponding":false},{"id":882704,"name":"Sâmela Farias","orcid":null,"position":3,"is_corresponding":false},{"id":881936,"name":"Sandro Patroca da Silva","orcid":"0000-0001-7185-4538","position":4,"is_corresponding":false},{"id":881937,"name":"Stella M. Chenet","orcid":"0000-0002-5305-0664","position":5,"is_corresponding":false},{"id":745770,"name":"Eduardo José Melo dos Santos","orcid":"0000-0001-5134-5648","position":6,"is_corresponding":false},{"id":881938,"name":"Luann Wendel Pereira de Sena","orcid":"0000-0001-9363-5766","position":7,"is_corresponding":false},{"id":881939,"name":"Flávia Póvoa da Costa","orcid":"0000-0002-5667-0754","position":8,"is_corresponding":false},{"id":882705,"name":"Amanda G.N. Cardoso-Mello","orcid":null,"position":9,"is_corresponding":false},{"id":881940,"name":"Paola Marchesini","orcid":"0000-0002-2051-5517","position":10,"is_corresponding":false},{"id":811629,"name":"Cássio Peterka","orcid":"0000-0003-2184-5531","position":11,"is_corresponding":false},{"id":881941,"name":"Giselle Maria Rachid Viana","orcid":"0000-0003-1771-7211","position":12,"is_corresponding":false},{"id":882706,"name":"Alexandre Macedo de Oliveira","orcid":null,"position":13,"is_corresponding":false},{"id":882702,"name":"Nathália Nogueira Chamma-Siqueira","orcid":null,"position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":null,"created_at":"2026-07-19T00:23:43.438539Z","pmid":"35353962","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}