{"doi":"10.1056/nejmoa1914919","title":"WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition","abstract":"BACKGROUND: mutations. In a previous study, we found that the E3 ubiquitin ligase WWP1 negatively regulates the function of PTEN. METHODS: variants. RESULTS: variants resulted in gain-of-function effects, which led to aberrant enzymatic activation with consequent PTEN inactivation, thereby triggering hyperactive growth-promoting PI3K signaling in cellular and murine models. CONCLUSIONS: as a cancer-susceptibility gene through direct aberrant regulation of the PTEN-PI3K signaling axis. (Funded by the National Institutes of Health and others.).","journal":"New England Journal of Medicine","year":2020,"id":57295,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298853,"name":"Lamis Yehia","orcid":"0000-0002-6389-3059","position":1,"is_corresponding":false},{"id":298854,"name":"Takahiro Kishikawa","orcid":"0000-0002-8602-5916","position":2,"is_corresponding":false},{"id":298855,"name":"Ying Ni","orcid":"0000-0002-0338-5239","position":3,"is_corresponding":false},{"id":298856,"name":"Brandie Heald","orcid":"0000-0003-4227-3675","position":4,"is_corresponding":false},{"id":272399,"name":"Jinfang Zhang","orcid":"0000-0001-8487-6007","position":5,"is_corresponding":false},{"id":300268,"name":"Nivedita Panch","orcid":null,"position":6,"is_corresponding":false},{"id":272392,"name":"Jing Liu","orcid":"0000-0002-3113-4015","position":7,"is_corresponding":false},{"id":231158,"name":"Wenyi Wei","orcid":"0000-0003-0512-3811","position":8,"is_corresponding":false},{"id":228051,"name":"Charis Eng","orcid":"0000-0002-3693-5145","position":9,"is_corresponding":false},{"id":23892,"name":"Pier Paolo Pandolfi","orcid":"0000-0002-5352-5295","position":10,"is_corresponding":false},{"id":298852,"name":"Yu-Ru Lee","orcid":"0000-0001-6592-6806","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"32459922","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}