{"doi":"10.1056/nejme2118899","title":"CAR T-Cell Therapy for Large B-Cell Lymphoma — Who, When, and How?","abstract":"Large B-cell lymphoma is a spectrum of aggressive B-cell cancers with broad genetic and clinical heterogeneity.1 First-line chemotherapy cures most patients, but those with relapsed or refractory disease usually die of lymphoma. Salvage chemotherapy followed by autologous stem-cell transplantation (ASCT) is the standard second-line approach to large B-cell lymphoma and cures up to 30 to 40% of eligible patients, but it is restricted to younger, fit patients and is relatively ineffective in chemotherapy-refractory disease.2 Chimeric antigen receptor (CAR) T-cell therapies that target CD19 have advanced the treatment of multiply relapsed large B-cell lymphoma and showed promising rates of durable remission . . .","journal":"New England Journal of Medicine","year":2021,"id":153298,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9479,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":262406,"name":"Dan L. Longo","orcid":"0000-0002-5850-5998","position":1,"is_corresponding":false},{"id":35694,"name":"Wyndham H. Wilson","orcid":"0000-0002-2862-9711","position":2,"is_corresponding":false},{"id":233601,"name":"Mark Roschewski","orcid":"0000-0003-0278-2635","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-18T23:43:39.820288Z","pmid":"34904797","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}