{"doi":"10.1055/s-2005-919446","title":"Cold pain converts into burning pain - thermosensitivity of menthol activated C nociceptors","abstract":null,"journal":"Aktuelle Neurologie","year":2005,"id":681583,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1780794,"name":"T Mühlbacher","orcid":null,"position":1,"is_corresponding":false},{"id":1780795,"name":"R Amschler","orcid":null,"position":2,"is_corresponding":false},{"id":1780796,"name":"A Binder","orcid":null,"position":3,"is_corresponding":false},{"id":1780797,"name":"J Schattschneider","orcid":null,"position":4,"is_corresponding":false},{"id":1780799,"name":"J Ludwig","orcid":null,"position":5,"is_corresponding":false},{"id":1780801,"name":"R Maag","orcid":null,"position":6,"is_corresponding":false},{"id":1780803,"name":"R Baron","orcid":null,"position":7,"is_corresponding":false},{"id":1780793,"name":"G Wasner","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cold pain converts into burning pain - thermosensitivity of menthol activated C nociceptors","abstract":"Introduction : Cold hyperalgesia is an important, but poorly understood symptom in neuropathic pain. A new model for cold pain showed that menthol acts to sensitize cold sensitive peripheral C nociceptors and activates cold specific A delta fibers by a cold channel (TRPM8). It is unclear at which environmental temperatures cold specific C nociceptors are activated by menthol. Methods : In 11 subjects menthol was topically applied to the forearm during local warming (39°C) and cooling (13°C). The skin was warmed and cooled, respectively, 5min prior to menthol and the skin temperature was kept constant during the 15min of menthol application. In a second approach menthol was applied on warm and cold skin during a selective A fiber block. Subjects rated temperature and pain sensations on NRS (temperature: -10 to +10, pain: 0 to 10). Investigations adhered to the Helsinki Declaration. Results : Warming of intact and A fiber-blocked skin induced a painless warm sensation prior to menthol and a warm sensation combined with significant burning pain during menthol. Cooling of intact skin induced a painless cold sensation prior to menthol which was reduced and accompanied by only moderate pain during menthol. During A fiber block menthol on cooled skin induced a significant pain without any temperature sensation. Conclusions : Cold specific C nociceptors are active in warm environment after menthol-sensitization and mediate ongoing pain. We suggest that the thermal range of the cold channel TRPM8 was extended after menthol-sensitization. Thus, pathologically sensitized cold nociceptors may cause spontaneous pain also in warm environments in patients with cold hyperalgesia. Menthol-induced pain was reduced in cooled skin due to central inhibition of C nociceptors exerted by concomitant activation of cold specific A fibers. Supported by the Alexander von Humboldt-Stifung, the DFG (Ba 1921/1–3), the BMBF (DNFS, 01EM01/04) and Pfizer Deutschland (unrestricted educational grant)","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2332176900","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.19793443,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/DOI/DOI?10.1055/s-2005-919446","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-2005-919446","host_type":"journal"}],"fields_of_study":["Pain Mechanisms and Treatments","Pain Management and Placebo Effect","Pharmacological Receptor Mechanisms and Effects"],"mesh_terms":[],"keywords":["Nociceptor","TRPM8","Menthol","Hyperalgesia","Cold sensitivity","Transient receptor potential channel","Neuropathic pain","Nociception","Medicine","Anesthesia","TRPV1","Chemistry","Receptor","Internal medicine","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T18:10:40.069788Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}