{"doi":"10.1055/s-2005-870228","title":"Effect of High-fat Diet on KKA<sup>y</sup>and<i>ob/ob</i>Mouse Liver and Adipose Tissue Corticosterone and 11-dehydrocorticosterone Concentrations","abstract":null,"journal":"Hormone and Metabolic Research","year":2005,"id":639893,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1662879,"name":"Y. Rönquist-Nii","orcid":null,"position":1,"is_corresponding":false},{"id":1662880,"name":"C. Larsson","orcid":null,"position":2,"is_corresponding":false},{"id":1662881,"name":"G. Klingström","orcid":null,"position":3,"is_corresponding":false},{"id":1662882,"name":"L. Engblom","orcid":null,"position":4,"is_corresponding":false},{"id":1662883,"name":"N. Edling","orcid":null,"position":5,"is_corresponding":false},{"id":1662884,"name":"V. Lidell","orcid":null,"position":6,"is_corresponding":false},{"id":1662885,"name":"I. Berg","orcid":null,"position":7,"is_corresponding":false},{"id":1662886,"name":"P.-O. Edlund","orcid":null,"position":8,"is_corresponding":false},{"id":1662887,"name":"M. Ashkzari","orcid":null,"position":9,"is_corresponding":false},{"id":1662888,"name":"N. Sahaf","orcid":null,"position":10,"is_corresponding":false},{"id":1662889,"name":"S. Norling","orcid":null,"position":11,"is_corresponding":false},{"id":1662890,"name":"V. Berggren","orcid":null,"position":12,"is_corresponding":false},{"id":1662891,"name":"K. Bergdahl","orcid":null,"position":13,"is_corresponding":false},{"id":1662892,"name":"M. Forsgren","orcid":null,"position":14,"is_corresponding":false},{"id":1662893,"name":"L. Abrahmsén","orcid":null,"position":15,"is_corresponding":false},{"id":1662878,"name":"P. Alberts","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effect of High-fat Diet on KKA<sup>y</sup>and<i>ob/ob</i>Mouse Liver and Adipose Tissue Corticosterone and 11-dehydrocorticosterone Concentrations","abstract":"The present study was performed to compare glucocorticoid levels in obese KKA (y) and ob/ob mice with those in normal C57BL/6J mice, and the effect of high-fat diet on glucocorticoids in KKA (y) and ob/ob mice. Liver, mesenteric and epididymal adipose tissue corticosterone and 11-dehydrocorticosterone concentrations as well as circulating corticosterone concentrations were measured. The KKA (y) and ob/ob mice displayed elevated serum corticosterone levels compared to normal mice, 2.0 to 2.8-fold in KKA (y), and 11 to 16-fold in ob/ob mice. Liver corticosterone levels were 3.0 to 5.1 and 6.2 to 8.1-fold, and 11-dehydrocorticosterone levels were 3.4 to 3.6 and 6.7 to 8.2-fold higher in KKA (y) and ob/ob mice compared to normal mice. Mesenteric adipose tissue corticosterone levels were 2.7 to 4.2-fold higher, and 11-dehydrocorticosterone levels were 2 to 4-fold higher in ob/ob than in KKA (y) mice. Epididymal adipose tissue corticosterone levels were 3.0 to 6.2-fold higher, and 11-dehydrocorticosterone levels were 1.8 to 2.0-fold higher in ob/ob than in KKA (y) mice. Circulating, hepatic, and mesenteric and epididymal adipose tissue glucocorticoid concentrations were low in the normal C57BL/6J mouse, high in the ob/ob mouse, and intermediate in the KKA (y) mouse. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mRNA levels were doubled in ob/ ob compared to KKA (y) mice in all three tissues. Glucocorticoid concentrations correlated with 11beta-HSD1 mRNA levels. High-fat diet had no effect on the tissue glucocorticoid concentrations.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16034710","pmcid":null,"openalex_id":"https://openalex.org/W1985540243","authors":[],"funders":[],"total_grants":0,"fwci":1.7968,"citation_percentile":0.84133067,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":3},{"year":2021,"count":1},{"year":2023,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-870228.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-2005-870228","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16034710","host_type":"repository"}],"fields_of_study":["Hormonal Regulation and Hypertension","Diet and metabolism studies","Birth, Development, and Health","11-beta-Hydroxysteroid Dehydrogenases","Adipose Tissue","Animals","Blood Glucose","Chromatography, Liquid","Corticosterone","Diabetes Mellitus","Diet","Dietary Fats","Epididymis","Insulin","Liver","Male","Mice","Mice, Inbred C57BL","Mice, Inbred Strains","Mice, Obese","RNA, Messenger","Radioimmunoassay","Reverse Transcriptase Polymerase Chain Reaction","Spectrometry, Mass, Electrospray Ionization"],"mesh_terms":["Adipose Tissue","Animals","Blood Glucose","Chromatography, Liquid","Corticosterone","Diabetes Mellitus","Diet","Dietary Fats","Epididymis","Insulin","Liver","Male","Mice, Inbred C57BL","Mice, Inbred Strains","Mice, Obese","Radioimmunoassay","RNA, Messenger","Reverse Transcriptase Polymerase Chain Reaction","Spectrometry, Mass, Electrospray Ionization","11-beta-Hydroxysteroid Dehydrogenases","Mice"],"keywords":["Endocrinology","Internal medicine","Corticosterone","Adipose tissue","Glucocorticoid","Biology","Chemistry","Medicine","Hormone"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T03:45:40.472453Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}