{"doi":"10.1055/s-2001-12011","title":"Artery Relaxation by Chalcones Isolated from the Roots of Angelica keiskei","abstract":null,"journal":"Planta Medica","year":2001,"id":603168,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1547221,"name":"Yoshiyuki Kimura","orcid":null,"position":1,"is_corresponding":false},{"id":160646,"name":"Koji Nakata","orcid":null,"position":2,"is_corresponding":false},{"id":160644,"name":"Kimiye Baba","orcid":null,"position":3,"is_corresponding":false},{"id":1547223,"name":"Hiromichi Okuda","orcid":null,"position":4,"is_corresponding":false},{"id":1547220,"name":"Masaharu Matsuura","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Artery Relaxation by Chalcones Isolated from the Roots of Angelica keiskei","abstract":"An EtOAc-soluble fraction from a 50% EtOH extract of the roots of Angelica keiskei inhibited phenylephrine-induced vasoconstriction in rat aortic rings, while an EtOAc-insoluble fraction had no effect at 100 micrograms/ml. Five active substances isolated from the EtOAc-soluble fraction of the roots were identified as xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols B (3), E (4) and F (5), which inhibited phenylephrine-induced vasoconstriction at the concentrations of 10-100 micrograms/ml. It was found that xanthoangelol (1), 4-hydroxyderricin (2), and xanthoangelols E (4) and F (5) inhibited the phenylephrine-induced vasoconstriction through endothelium-dependent endothelium-derived relaxing factor (EDRF) production and/or nitric oxide (NO) production. Among the five chalcones, xanthoangelol B (3) inhibited the phenylephrine-induced vasoconstriction most strongly, and it inhibited the phenylephrine-induced vasoconstriction in the presence or absence of endothelium and in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) (an NO synthetase inhibitor). Furthermore, 4-hydroxyderricin (2) and xanthoangelol B (3) at concentrations of 10-100 micrograms/ml concentration-dependently inhibited the elevation of intracellular free calcium [Ca2+]i induced by phenylephrine. These results demonstrate that compounds 1, 2, 4 and 5 inhibit phenylephrine-induced vasoconstriction through endothelium-dependent production of EDRF/NO and/or through the reduction of the [Ca2+]i elevation induced by phenylephrine. On the other hand, the inhibitory mechanism of compound 3 on phenylephrine-induced vasoconstriction might involve the direct inhibition of smooth muscle functions through the reduction of [Ca2+]i elevation without affecting EDRF/NO production.","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11345693","pmcid":null,"openalex_id":"https://openalex.org/W2082759617","authors":[],"funders":[],"total_grants":0,"fwci":2.2949,"citation_percentile":0.89993037,"influential_citations":0,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":3},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":5},{"year":2020,"count":4},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2024,"count":2},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-12011.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-2001-12011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11345693","host_type":"repository"}],"fields_of_study":["Traditional Chinese Medicine Analysis","Traditional and Medicinal Uses of Annonaceae","Bioactive natural compounds"],"mesh_terms":["Animals","Aorta","Calcium","Cells, Cultured","Chalcone","Cyclic GMP","Male","Muscle Contraction","Muscle Relaxation","Muscle, Smooth, Vascular","Nitric Oxide","Phenylephrine","Plant Extracts","Rabbits","Vasoconstriction","Vasoconstrictor Agents","Vasodilation","Rats, Wistar","Plant Roots","Apiaceae","Culture Techniques","Rats"],"keywords":["Phenylephrine","Vasoconstriction","Chemistry","Endothelium","Nitric oxide","Pharmacology","Vasodilation","Medicine","Anesthesia","Internal medicine","Blood pressure","Organic chemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T21:17:25.426522Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}