{"doi":"10.1055/s-0041-1727368","title":"Increased Fgf21 expression in visceral adipose tissue (VAT) of diet-induced obese (DIO) mice correlates with DNA hypermethylation in the 5ʹUTR of Fgf21","abstract":null,"journal":"Diabetologie und Stoffwechsel","year":2021,"id":614184,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1582641,"name":"N Taege","orcid":null,"position":1,"is_corresponding":false},{"id":1582642,"name":"C Geißler","orcid":null,"position":2,"is_corresponding":false},{"id":1582643,"name":"H Kirchner","orcid":null,"position":3,"is_corresponding":false},{"id":1582640,"name":"JH Britsemmer","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Increased Fgf21 expression in visceral adipose tissue (VAT) of diet-induced obese (DIO) mice correlates with DNA hypermethylation in the 5ʹUTR of Fgf21","abstract":"Objective Fibroblast growth factor 21 (FGF21) improves weight loss, glucose metabolism and insulin signaling. FGF21 is mainly expressed in the liver, but acts in the adipose tissue. Obesity is associated with changes in DNA methylation, which alters gene expression. Therefore, we aim to study the epigenetic regulation of Fgf21 and if it is associated to the impaired FGF21 signaling observed in human and murine adipose tissue.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W3168741903","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.08949535,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1055/s-0041-1727368","host_type":"journal"}],"fields_of_study":["Fibroblast Growth Factor Research","Epigenetics and DNA Methylation"],"mesh_terms":[],"keywords":["FGF21","Adipose tissue","DNA methylation","Endocrinology","Internal medicine","Epigenetics","White adipose tissue","Fibroblast growth factor","Biology","Gene expression","Medicine","Gene","Receptor","Genetics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T11:21:16.884205Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}