{"doi":"10.1055/s-0040-1713844","title":"Autonomic Dysfunction in the Synucleinopathies","abstract":"<jats:title>Abstract</jats:title><jats:p>Autonomic dysfunction is a characteristic feature in the synucleinopathies. Differences in cellular deposition and neuronal populations affected by α-synuclein aggregation influence the manifestations and severity of autonomic failure in the different synucleinopathy disorders. The Lewy body disorders (Parkinson's disease, dementia with Lewy bodies, and pure autonomic failure) have predominantly peripheral involvement, whereas multiple system atrophy chiefly manifests as central autonomic failure. Clinical and laboratory features may be useful in distinguishing the different synucleinopathies based on the pattern and severity of autonomic failure. Treatment recommendations are aimed at the underlying pathophysiology and utilize non-pharmacologic and pharmacologic approaches. This review will focus on pathophysiology, clinical manifestations, and management recommendations for autonomic failure including neurogenic orthostatic hypotension, thermoregulatory dysfunction, genitourinary dysfunction, and gastrointestinal dysfunction in the synucleinopathies.</jats:p>","journal":"Seminars in Neurology","year":2020,"id":682689,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":428949,"name":"Elizabeth A. Coon","orcid":"0000-0003-1206-0222","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Autonomic Dysfunction in the Synucleinopathies","abstract":"<jats:title>Abstract</jats:title><jats:p>Autonomic dysfunction is a characteristic feature in the synucleinopathies. Differences in cellular deposition and neuronal populations affected by α-synuclein aggregation influence the manifestations and severity of autonomic failure in the different synucleinopathy disorders. The Lewy body disorders (Parkinson's disease, dementia with Lewy bodies, and pure autonomic failure) have predominantly peripheral involvement, whereas multiple system atrophy chiefly manifests as central autonomic failure. Clinical and laboratory features may be useful in distinguishing the different synucleinopathies based on the pattern and severity of autonomic failure. Treatment recommendations are aimed at the underlying pathophysiology and utilize non-pharmacologic and pharmacologic approaches. This review will focus on pathophysiology, clinical manifestations, and management recommendations for autonomic failure including neurogenic orthostatic hypotension, thermoregulatory dysfunction, genitourinary dysfunction, and gastrointestinal dysfunction in the synucleinopathies.</jats:p>","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32906169","pmcid":null,"openalex_id":"https://openalex.org/W3083973868","authors":[],"funders":[],"total_grants":0,"fwci":1.3448,"citation_percentile":0.84756772,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":3},{"year":2022,"count":8},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1713844.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-0040-1713844","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32906169","host_type":"repository"}],"fields_of_study":["Parkinson's Disease Mechanisms and Treatments","Cardiovascular Syncope and Autonomic Disorders","Botulinum Toxin and Related Neurological Disorders","Autonomic Nervous System Diseases","Humans","Lewy Body Disease","Multiple System Atrophy","Parkinson Disease"],"mesh_terms":["Autonomic Nervous System Diseases","Humans","Parkinson Disease","Multiple System Atrophy","Lewy Body Disease"],"keywords":["Synucleinopathies","Pure autonomic failure","Medicine","Dementia with Lewy bodies","Atrophy","Orthostatic vital signs","Neuroscience","Disease","Dementia","Lewy body","Autonomic nervous system","Parkinson's disease","Pathology","Internal medicine","Alpha-synuclein","Psychology","Blood pressure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T21:06:58.335890Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}