{"doi":"10.1055/s-0030-1261886","title":"Disruption of Endothelial Tight Junctions in a Patient with Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS)","abstract":null,"journal":"Neuropediatrics","year":2010,"id":598077,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1532352,"name":"R. Takahashi","orcid":null,"position":1,"is_corresponding":false},{"id":3990,"name":"T. Nakayama","orcid":null,"position":2,"is_corresponding":false},{"id":1532355,"name":"K. Shishikura","orcid":null,"position":3,"is_corresponding":false},{"id":26941,"name":"H. Suzuki","orcid":"0000-0002-6375-5596","position":4,"is_corresponding":false},{"id":1532358,"name":"Y. Hirayama","orcid":null,"position":5,"is_corresponding":false},{"id":1283548,"name":"M. Osawa","orcid":null,"position":6,"is_corresponding":false},{"id":819625,"name":"H. Oda","orcid":null,"position":7,"is_corresponding":false},{"id":1532349,"name":"M. Matsuzaki","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Disruption of Endothelial Tight Junctions in a Patient with Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS)","abstract":"An electron microscopic study revealed disruption of capillary endothelial tight junctions (TJs) in both biopsied muscle, taken at 5 years and 1 month of age, and the autopsied brain, taken at 13 years and 6 months of age, in a patient with mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) and mitochondrial DNA (mtDNA) point mutation A3243G. This endothelial barrier disruption might result in vasogenic edema and systemic lactic acidosis, possibly the critical pathology of MELAS.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20799154","pmcid":null,"openalex_id":"https://openalex.org/W2049577644","authors":[],"funders":[],"total_grants":0,"fwci":0.8055,"citation_percentile":0.71304373,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2016,"count":2},{"year":2019,"count":1},{"year":2020,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1261886.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-0030-1261886","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20799154","host_type":"repository"}],"fields_of_study":["Mitochondrial Function and Pathology","Metabolism and Genetic Disorders","Trace Elements in Health","Adolescent","Brain","DNA, Mitochondrial","Disease Progression","Female","Humans","MELAS Syndrome","Microscopy, Electron, Transmission","Point Mutation","Tight Junctions","Ultrasonography"],"mesh_terms":["Adolescent","Brain","DNA, Mitochondrial","Female","Humans","Ultrasonography","MELAS Syndrome","Point Mutation","Disease Progression","Tight Junctions","Microscopy, Electron, Transmission"],"keywords":["Mitochondrial encephalomyopathy","Lactic acidosis","MELAS syndrome","Medicine","Acidosis","Mitochondrial DNA","Stroke (engine)","Pathology","Mitochondrial myopathy","Cardiology","Internal medicine","Biology","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T14:59:38.357882Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}