{"doi":"10.1055/s-0030-1249006","title":"Associations of Estrogen Receptor Alpha and Beta Gene Polymorphisms with Sex Steroid Levels and Body Fat Content in Men","abstract":null,"journal":"Experimental and Clinical Endocrinology & Diabetes","year":2010,"id":635484,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648738,"name":"Z. Efstathiadou","orcid":null,"position":1,"is_corresponding":false},{"id":1648739,"name":"S. Polyzos","orcid":null,"position":2,"is_corresponding":false},{"id":1648740,"name":"M. Goutou","orcid":null,"position":3,"is_corresponding":false},{"id":1648741,"name":"N. Stakias","orcid":null,"position":4,"is_corresponding":false},{"id":1648742,"name":"G. Koukoulis","orcid":null,"position":5,"is_corresponding":false},{"id":1648737,"name":"C. Sakka","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Associations of Estrogen Receptor Alpha and Beta Gene Polymorphisms with Sex Steroid Levels and Body Fat Content in Men","abstract":"OBJECTIVE: Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in Estrogen Receptor α ( ESR1) and Estrogen Receptor β ( ESR2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men. DESIGN AND METHODS: SHBG, total and calculated free testosterone (TT and cal FT), estradiol (E2) and free Estradiol (FE2) were determined in a population-based cohort of 170 apparently healthy Greek men. Body mass index (BMI), waist circumference (WC) and percentage of body fat (%fat) content were measured in all participants. Genotyping for the PVU II and XBA I polymorphisms of the ESR1 gene and for the RSA I and ALU I polymorphisms of the ESR2 gene was performed. RESULTS: PVU II showed an association with E2 levels [median (IQR) pp 58.5 (42.1-73.4) pg/ml vs. Pp 48.8 (42.9-60.1) and PP 57.7 (44-70.5), p=0.032], and with %fat [mean±SD pp 24.6±5.3 vs. Pp 22.4±5.2 and PP 21.2±6.7, p=0.044], after adjustment for age and WC. Furthermore, the effect of PVU II on E2 was independent of %fat (p=0.038). A synergistic effect of the two ESR1 polymorphisms on E2 (p=0.023), FE2 (p=0.03) and %fat (p=0.004) was present. Finally, a synergistic effect of the ESR1 and ESR2 genes on TT (p=0.009), independent of age, WC and %fat also emerged. CONCLUSIONS: Genetic variation in ESR1 is associated with serum estradiol levels and body fat content regulation in men. Furthermore, a synergistic effect of ESR1 and ESR2 genes is exerted on serum testosterone levels.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20200813","pmcid":null,"openalex_id":"https://openalex.org/W2092819265","authors":[],"funders":[],"total_grants":0,"fwci":0.1756,"citation_percentile":0.60983999,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":2},{"year":2018,"count":1},{"year":2019,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1249006.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-0030-1249006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20200813","host_type":"repository"},{"url":"http://hdl.handle.net/11615/32774","host_type":"repository"}],"fields_of_study":["Estrogen and related hormone effects","Hormonal and reproductive studies","Menopause: Health Impacts and Treatments","Adipose Tissue","Adiposity","Adult","Body Composition","Estrogen Receptor alpha","Estrogen Receptor beta","Genetic Association Studies","Gonadal Steroid Hormones","Greece","Humans","Male","Middle Aged","Osmolar Concentration","Polymorphism, Genetic","Sex Factors","Young Adult"],"mesh_terms":["Adipose Tissue","Adult","Body Composition","Greece","Humans","Male","Middle Aged","Osmolar Concentration","Polymorphism, Genetic","Sex Factors","Gonadal Steroid Hormones","Estrogen Receptor alpha","Estrogen Receptor beta","Adiposity","Young Adult","Genetic Association Studies"],"keywords":["Sex hormone-binding globulin","Estrogen receptor alpha","Endocrinology","Estrogen receptor beta","Internal medicine","Estrogen","Estrogen receptor","Sex steroid","Single-nucleotide polymorphism","Estrogen-related receptor alpha","BETA (programming language)","Hormone","Alpha (finance)","Biology","Gene","Medicine","Steroid","Genotype","Genetics","Cancer","Breast cancer","Androgen"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:10:05.906061Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}