{"doi":"10.1055/s-0029-1218685","title":"Synthesis of Bis(N-acylamidines) from Amidines and N-Acylbenzotriazoles","abstract":null,"journal":"Synthesis","year":2010,"id":682981,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":9,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1784235,"name":"Juliana Clodt","orcid":null,"position":1,"is_corresponding":false},{"id":1784237,"name":"Verena Hack","orcid":null,"position":2,"is_corresponding":false},{"id":177484,"name":"Roland Fröhlich","orcid":null,"position":3,"is_corresponding":false},{"id":1784233,"name":"Ernst-Ulrich Würthwein","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synthesis of Bis(N-acylamidines) from Amidines and N-Acylbenzotriazoles","abstract":"Bis(N-acylamidines) 7, linked by a spacer connected to the carboxyl groups, were synthesized in moderate to good yields from bis(N-acylbenzotriazoles) 6 and amidines 2. In contrast, the corresponding bis(carboxylic acid) chlorides were not well suited for the synthesis of the compounds 7. 2-Aminothiazole gave the bis-amide 8, where the amidine moieties are part of heterocyclic ring systems. Furthermore, the reaction of a bis-amidine 9 with two equivalents of N-benzoylbenzotriazole (10) gave the bifunctional N-acylamidine 11, linked to the spacer at the amidine carbon atoms. All substances were thoroughly characterized including nine X-ray diffraction studies.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":9,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W2004552177","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.06557739,"influential_citations":0,"citation_trend":[{"year":2016,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0029-1218685.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/s-0029-1218685","host_type":"journal"}],"fields_of_study":["Quinazolinone synthesis and applications","Synthesis and biological activity","Multicomponent Synthesis of Heterocycles"],"mesh_terms":[],"keywords":["Amidine","Chemistry","Bifunctional","Amide","Ring (chemistry)","Medicinal chemistry","Stereochemistry","Organic chemistry","Catalysis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[{"doi":"10.5517/cctc8v8","title":"CCDC 755620: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8t7","title":"CCDC 755619: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8s6","title":"CCDC 755618: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8r5","title":"CCDC 755617: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8q4","title":"CCDC 755616: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8p3","title":"CCDC 755615: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8m1","title":"CCDC 755613: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8n2","title":"CCDC 755614: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/cctc8l0","title":"CCDC 755612: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T21:54:20.974171Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}