{"doi":"10.1055/a-2714-3368","title":"Chlorothiazide Is Associated with a Weaker Diuretic Response than Furosemide in Infants with Bronchopulmonary Dysplasia","abstract":"Objective: This study aimed to compare the acute diuretic effect of furosemide versus chlorothiazide in preterm infants with high-grade bronchopulmonary dysplasia (BPD). Study Design: We conducted a retrospective cohort study of infants with grade 2 or 3 BPD admitted to a level IV NICU between 36 and 60 weeks postmenstrual age. Novel diuretic exposures were defined as administration of furosemide or chlorothiazide without prior exposure to the same agent in the preceding 7 days. The primary outcome was the within-subject change in net fluid balance (mL/kg) in the 24 hours before and after diuretic initiation. Multivariable linear regression was performed adjusted for diuretic dosing, route, frequency, and clinical covariates. Results: = 0.032). Concomitant use of both agents was common, yet the order of administration did not significantly influence fluid balance. No other clinical or biochemical characteristics were significantly associated with diuretic response. Conclusion: Furosemide has a significantly greater acute diuretic effect than chlorothiazide in infants with high-grade BPD. These findings may inform short-term fluid management strategies and support further investigation into optimal diuretic selection and dosing in this population. Key Points: · Furosemide has a greater acute diuretic effect than chlorothiazide in infants with grade 2/3 BPD.. · More frequent dosing was associated with greater diuretic effect than daily dosing for both agents.. · Concomitant use of both agents was common; the order of administration did not impact fluid balance..","journal":"American Journal of Perinatology","year":2025,"id":576769,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":966718,"name":"Matthew Huber","orcid":"0000-0002-9441-7477","position":1,"is_corresponding":false},{"id":1298833,"name":"Heidi Morris","orcid":"0000-0001-9128-2151","position":2,"is_corresponding":false},{"id":428052,"name":"Erik A. Jensen","orcid":"0000-0002-9179-8032","position":3,"is_corresponding":false},{"id":1228943,"name":"Kathleen Gibbs","orcid":null,"position":4,"is_corresponding":false},{"id":355528,"name":"Sara B. DeMauro","orcid":"0000-0003-1647-4000","position":5,"is_corresponding":false},{"id":1485607,"name":"Avery W. Zierk","orcid":"0000-0002-9878-2500","position":6,"is_corresponding":false},{"id":1228944,"name":"Nicolas P. Goldstein Novick","orcid":null,"position":7,"is_corresponding":false},{"id":875337,"name":"David M. Rub","orcid":"0000-0003-3687-7325","position":8,"is_corresponding":false},{"id":1486020,"name":"A. Lawin O'Brien","orcid":null,"position":9,"is_corresponding":false},{"id":258995,"name":"Scott A. Lorch","orcid":"0000-0003-3855-6752","position":10,"is_corresponding":false},{"id":793867,"name":"Nicolas A. Bamat","orcid":"0000-0001-6427-093X","position":11,"is_corresponding":false},{"id":1228498,"name":"Timothy D. Nelin","orcid":"0000-0002-7435-2610","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:58:00.620755Z","pmid":"41043471","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}