{"doi":"10.1055/a-2589-5099","title":"Transient N-Aziridinyl Radicals in Olefin Functionalization","abstract":"Abstract Aziridines are the smallest nitrogen-containing heterocycles and are responsible for the biological activity of aziridine-natural products and active pharmaceutical ingredients (APIs). Classically, aziridines are prepared from acyclic precursors via 1) [2+1] cycloaddition of a nitrene equivalent with an olefin, 2) [2+1] cycloaddition of a carbene equivalent with an imine, or 3) via intramolecular cyclization of β-functionalized amines. In comparison, introduction of intact aziridines is an uncommon disconnection. Here, we highlight the recent development of N-aziridinyl radicals as novel intermediates in synthetic chemistry that enable olefin hydroxyaziridination. These intermediates, generated by photoredox activation of N-pyridinium aziridine precursors, afford access to products of a heretofore unknown epoxide opening with N-aziridine nucleophiles and introduce new disconnections of olefin aziridination chemistry. 1 Introduction 2 Classical Aziridination Methods 3 Aziridine-Group Transfer 4 Conclusions","journal":"Synlett","year":2025,"id":564315,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1218650,"name":"Promita Biswas","orcid":"0000-0002-6779-6061","position":1,"is_corresponding":false},{"id":298861,"name":"David C. Powers","orcid":"0000-0003-3717-2001","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:56:20.933088Z","pmid":"41959885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}