{"doi":"10.1055/a-2285-4923","title":"2-Hydroxyglutarate as an MR spectroscopic predictor of an IDH mutation in gliomas","abstract":"<jats:title>Abstract</jats:title><jats:p>The mutated enzyme isocitrate dehydrogenase (IDH) 1 and 2 has been detected in various tumor entities such as gliomas and can convert α-ketoglutarate into the oncometabolite 2-hydroxyglutarate (2-HG). This neuro-oncologically significant metabolic product can be detected by MR spectroscopy and is therefore suitable for noninvasive glioma classification and therapy monitoring.</jats:p><jats:p>This paper provides an up-to-date overview of the methodology and relevance of 1H-MR spectroscopy (MRS) in the oncological primary and follow-up diagnosis of gliomas. The possibilities and limitations of this MR spectroscopic examination are evaluated on the basis of the available literature.</jats:p><jats:p>By detecting 2-HG, MRS can in principle offer a noninvasive alternative to immunohistological analysis thus avoiding surgical intervention in some cases. However, in addition to an adapted and optimized examination protocol, the individual measurement conditions in the examination region are of decisive importance. Due to the inherently small signal of 2-HG, unfavorable measurement conditions can influence the reliability of detection.</jats:p>","journal":"RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren","year":2024,"id":599826,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537383,"name":"Heiner N. 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This neuro-oncologically significant metabolic product can be detected by MR spectroscopy and is therefore suitable for noninvasive glioma classification and therapy monitoring.</jats:p><jats:p>This paper provides an up-to-date overview of the methodology and relevance of 1H-MR spectroscopy (MRS) in the oncological primary and follow-up diagnosis of gliomas. The possibilities and limitations of this MR spectroscopic examination are evaluated on the basis of the available literature.</jats:p><jats:p>By detecting 2-HG, MRS can in principle offer a noninvasive alternative to immunohistological analysis thus avoiding surgical intervention in some cases. However, in addition to an adapted and optimized examination protocol, the individual measurement conditions in the examination region are of decisive importance. Due to the inherently small signal of 2-HG, unfavorable measurement conditions can influence the reliability of detection.</jats:p>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38648790","pmcid":null,"openalex_id":"https://openalex.org/W4394992975","authors":[],"funders":[],"total_grants":0,"fwci":0.8654,"citation_percentile":0.71638289,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2285-4923.pdf","host_type":"journal"},{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2285-4923.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/a-2285-4923","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38648790","host_type":"repository"}],"fields_of_study":["Glioma Diagnosis and Treatment","Cancer, Hypoxia, and Metabolism","Advanced MRI Techniques and Applications","Glutarates","Isocitrate Dehydrogenase","Humans","Glioma","Brain Neoplasms","Mutation","Magnetic Resonance Spectroscopy","Biomarkers, Tumor","Sensitivity and Specificity"],"mesh_terms":["Brain Neoplasms","Glioma","Glutarates","Humans","Isocitrate Dehydrogenase","Mutation","Magnetic Resonance Spectroscopy","Sensitivity and Specificity","Biomarkers, Tumor"],"keywords":["Mutation","Cancer research","Medicine","Biology","Genetics","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:22:20.637558Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}