{"doi":"10.1055/a-2087-3003","title":"Risk Factors for Postdischarge Major Thromboembolism and Mortality in Hospitalized Patients with COVID-19 with Cardiovascular Comorbidities: Insights from the CORE-19 Registry","abstract":"Background Coronavirus disease 2019 (COVID-19) is associated with venous and arterial thromboembolism (VTE and ATE) and all-cause mortality (ACM) in hospitalized patients. High-quality data are needed on postdischarge outcomes in patients with cardiovascular disease. Objectives To analyze outcomes and identify risk factors for ATE, VTE, and ACM in a high-risk subgroup of hospitalized COVID-19 patients with baseline cardiovascular disease. Methods We investigated postdischarge rates and associated risk factors of ATE, VTE, and ACM in 608 hospitalized COVID-19 patients with coronary artery disease, carotid artery stenosis (CAS), peripheral arterial disease (PAD), or ischemic stroke. Results Through 90 days postdischarge, outcome rates were: ATE 27.3% (10.2% myocardial infarction, 10.1% ischemic stroke, 13.2% systemic embolism, 12.7% major adverse limb event); VTE 6.9% (4.1% deep vein thrombosis, 3.6% pulmonary embolism); composite of ATE, VTE, or ACM 35.2% (214/608). Multivariate analysis showed significant association between this composite endpoint and age >75 years (odds ratio [OR]: 1.90, 95% confidence interval [CI]: 1.22–2.94, p = 0.004), PAD (OR: 3.23, 95% CI: 1.80–5.81, p ≤ 0.0001), CAS (OR: 1.74, 95% CI: 1.11–2.75, p = 0.017), congestive heart failure (CHF) (OR: 1.84, 95% CI: 1.02–3.35, p = 0.044), previous VTE (OR: 3.08, 95% CI: 1.75–5.42, p < 0.0001), and intensive care unit (ICU) admission (OR: 2.93, 95% CI: 1.81–4.75, p < 0.0001). Conclusion COVID-19 inpatients with cardiovascular disease experience high rates of ATE, VTE, or ACM through 90 days postdischarge. Age >75 years, PAD, CAS, CHF, previous VTE, and ICU admission are independent risk factors.","journal":"Thrombosis and Haemostasis","year":2023,"id":363896,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8899,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":648105,"name":"Mark Goldin","orcid":"0000-0002-1147-5541","position":1,"is_corresponding":false},{"id":768644,"name":"Husneara Rahman","orcid":null,"position":2,"is_corresponding":false},{"id":715928,"name":"Cristina Sison","orcid":null,"position":3,"is_corresponding":false},{"id":495675,"name":"Martin Lesser","orcid":"0000-0002-0318-5739","position":4,"is_corresponding":false},{"id":696318,"name":"Sam Ngu","orcid":"0000-0002-2256-067X","position":5,"is_corresponding":false},{"id":1118681,"name":"James Tsang","orcid":null,"position":6,"is_corresponding":false},{"id":94690,"name":"Michael Qiu","orcid":"0000-0002-3841-7923","position":7,"is_corresponding":false},{"id":961024,"name":"Shreya Sanghani","orcid":null,"position":8,"is_corresponding":false},{"id":1118682,"name":"Jackson Yeh","orcid":null,"position":9,"is_corresponding":false},{"id":1118683,"name":"Miltiadis Matsagkas","orcid":null,"position":10,"is_corresponding":false},{"id":1118322,"name":"Eleni Αrnaoutoglou","orcid":"0000-0003-0441-9442","position":11,"is_corresponding":false},{"id":104080,"name":"Alex C. Spyropoulos","orcid":"0000-0002-3175-461X","position":12,"is_corresponding":false},{"id":648104,"name":"Dimitrios Giannis","orcid":"0000-0001-9246-976X","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:14:32.510714Z","pmid":"37146648","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}