{"doi":"10.1055/a-1989-1856","title":"Protein kinases: Role of their dysregulation in carcinogenesis,\n                    identification and inhibition","abstract":"<jats:title>Abstract</jats:title><jats:p>Protein kinases belong to the phosphor-transferases superfamily of enzymes, which\n                    “activate” enzymes via phosphorylation. The kinome of an\n                    organism is the total set of genes in the genome, which encode for all the\n                    protein kinases. Certain mutations in the kinome have been linked to\n                    dysregulation of protein kinases, which in turn can lead to several diseases and\n                    disorders including cancer. In this review, we have briefly discussed the role\n                    of protein kinases in various biochemical processes by categorizing cancer\n                    associated phenotypes and giving their protein kinase examples. Various\n                    techniques have also been discussed, which are being used to analyze the\n                    structure of protein kinases, and associate their roles in the oncogenesis. We\n                    have also discussed protein kinase inhibitors and United States Federal Drug\n                    Administration (USFDA) approved drugs, which target protein kinases and can\n                    serve as a counter to protein kinase dysregulation and mitigate the effects of\n                    oncogenesis. Overall, this review briefs about the importance of protein\n                    kinases, their roles in oncogenesis on dysregulation and how their inhibition\n                    via various drugs can be used to mitigate their effects.</jats:p>","journal":"Drug Research","year":2023,"id":601843,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":5615,"name":"Amit Singh","orcid":"0000-0001-9979-7221","position":1,"is_corresponding":false},{"id":918659,"name":"Pankaj Kumar","orcid":"0000-0002-8411-1634","position":2,"is_corresponding":false},{"id":1543279,"name":"Mahima Kaushik","orcid":null,"position":3,"is_corresponding":false},{"id":1543278,"name":"Niloy Sarkar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Protein kinases: Role of their dysregulation in carcinogenesis,\n                    identification and inhibition","abstract":"<jats:title>Abstract</jats:title><jats:p>Protein kinases belong to the phosphor-transferases superfamily of enzymes, which\n                    “activate” enzymes via phosphorylation. The kinome of an\n                    organism is the total set of genes in the genome, which encode for all the\n                    protein kinases. Certain mutations in the kinome have been linked to\n                    dysregulation of protein kinases, which in turn can lead to several diseases and\n                    disorders including cancer. In this review, we have briefly discussed the role\n                    of protein kinases in various biochemical processes by categorizing cancer\n                    associated phenotypes and giving their protein kinase examples. Various\n                    techniques have also been discussed, which are being used to analyze the\n                    structure of protein kinases, and associate their roles in the oncogenesis. We\n                    have also discussed protein kinase inhibitors and United States Federal Drug\n                    Administration (USFDA) approved drugs, which target protein kinases and can\n                    serve as a counter to protein kinase dysregulation and mitigate the effects of\n                    oncogenesis. Overall, this review briefs about the importance of protein\n                    kinases, their roles in oncogenesis on dysregulation and how their inhibition\n                    via various drugs can be used to mitigate their effects.</jats:p>","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36822216","pmcid":null,"openalex_id":"https://openalex.org/W4321605991","authors":[],"funders":[],"total_grants":0,"fwci":3.136,"citation_percentile":0.93413812,"influential_citations":0,"citation_trend":[{"year":2023,"count":10},{"year":2024,"count":4},{"year":2025,"count":8},{"year":2026,"count":5}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1989-1856.pdf","host_type":"journal"},{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1989-1856.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/a-1989-1856","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36822216","host_type":"repository"}],"fields_of_study":["Cancer-related Molecular Pathways","Chronic Lymphocytic Leukemia Research","Melanoma and MAPK Pathways"],"mesh_terms":["Humans","Neoplasms","Protein Kinases","Protein Kinase Inhibitors","Carcinogenesis"],"keywords":["Carcinogenesis","Kinase","Identification (biology)","Cancer research","Cell biology","Chemistry","Biology","Biochemistry","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T17:36:34.408711Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}