{"doi":"10.1055/a-1874-8548","title":"Is There Clinically Relevant Plasma Interference with ELISA Detection of APS Antibodies? Reproducibility of Real-World Paired Serum and Plasma Testing","abstract":"The detection of antiphospholipid antibodies is a cornerstone requisite practice in the evaluation and diagnosis of antiphospholipid syndrome (APS). APS is commonly characterized by the detection of persisting antiphospholipid antibodies in the clinical context of thrombotic or obstetric manifestations. The 2006 Sydney Criteria outline clinical criteria and define anticardiolipin (aCL), anti-β-2 glycoprotein-1 (β2GP1), and the lupus anticoagulant in classifying definite APS.[1] Other antibodies, including anti-phosphatidylserine-prothrombin (aPSPT), have been identified and linked to APS though their clinical utility remains an area of uncertainty and subject to ongoing research.","journal":"Thrombosis and Haemostasis","year":2022,"id":309272,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":910362,"name":"Giovanni Orsolini","orcid":"0000-0003-4119-3016","position":1,"is_corresponding":false},{"id":275610,"name":"Cynthia S. Crowson","orcid":"0000-0001-5847-7475","position":2,"is_corresponding":false},{"id":437793,"name":"Melissa R. Snyder","orcid":"0000-0002-5442-4699","position":3,"is_corresponding":false},{"id":755678,"name":"Rajiv K. Pruthi","orcid":"0000-0002-6969-929X","position":4,"is_corresponding":false},{"id":729076,"name":"Kevin G. Moder","orcid":null,"position":5,"is_corresponding":false},{"id":1004304,"name":"Michael M. Pham","orcid":"0000-0002-2430-8320","position":0,"is_corresponding":true}],"reference_count":7,"raw_metadata":null,"created_at":"2026-07-19T00:33:11.579763Z","pmid":"35697257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}