{"doi":"10.1055/a-1533-3085","title":"Recent Advances in the Construction of Quaternary Stereocenters via Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) provides an efficient and powerful strategy to construct quaternary stereocenters, which are widely present in biologically active natural products and approved drugs. In this short review, we summarize recent developments (since 2018) in the facile synthesis of quaternary stereocenters via DAAA methods. Several representative examples of the use of DAAA strategies for the total synthesis of complex natural products further demonstrate its synthetic potential in the realm of organic and medicinal chemistry.</jats:p>\n                  <jats:p>1 \tIntroduction</jats:p>\n                  <jats:p>2 \tConstruction of Quaternary Stereocenters via Palladium \tCatalyzed DAAA</jats:p>\n                  <jats:p>3 \tConstruction of Quaternary Stereocenters via Pd-Catalyzed \tInterceptive DAAA</jats:p>\n                  <jats:p>4 \tApplication of DAAA in Natural Product Synthesis</jats:p>\n                  <jats:p>5 \tConclusion</jats:p>","journal":"Synthesis","year":2021,"id":685553,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":630585,"name":"Ting Zhang","orcid":"0000-0001-9391-8926","position":1,"is_corresponding":false},{"id":1791098,"name":"Jitian Liu","orcid":null,"position":2,"is_corresponding":false},{"id":1791099,"name":"Xiaoxun Li","orcid":null,"position":3,"is_corresponding":false},{"id":1461675,"name":"Xinhui Yu","orcid":"0000-0002-5971-6164","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Recent Advances in the Construction of Quaternary Stereocenters via Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Palladium-catalyzed decarboxylative asymmetric allylic alkylation (DAAA) provides an efficient and powerful strategy to construct quaternary stereocenters, which are widely present in biologically active natural products and approved drugs. In this short review, we summarize recent developments (since 2018) in the facile synthesis of quaternary stereocenters via DAAA methods. Several representative examples of the use of DAAA strategies for the total synthesis of complex natural products further demonstrate its synthetic potential in the realm of organic and medicinal chemistry.</jats:p>\n                  <jats:p>1 \tIntroduction</jats:p>\n                  <jats:p>2 \tConstruction of Quaternary Stereocenters via Palladium \tCatalyzed DAAA</jats:p>\n                  <jats:p>3 \tConstruction of Quaternary Stereocenters via Pd-Catalyzed \tInterceptive DAAA</jats:p>\n                  <jats:p>4 \tApplication of DAAA in Natural Product Synthesis</jats:p>\n                  <jats:p>5 \tConclusion</jats:p>","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26207759","pmcid":null,"openalex_id":"https://openalex.org/W3175053346","authors":[],"funders":[{"funder_name":"Fundamental Research Fund of Shandong University","grant_id":"21310082164009","title":null},{"funder_name":"Fundamental Research Fund of Shandong University","grant_id":"21310088963023","title":null},{"funder_name":"Fundamental Research Fund of Shandong University","grant_id":"2020QNQT007","title":null},{"funder_name":"Fundamental Research Fund of Shandong University","grant_id":"2020QNQT009","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"21901142","title":null},{"funder_name":"Natural Science Foundation of Shandong Province","grant_id":"ZR2019QB001","title":null},{"funder_name":"Natural Science Foundation of Shandong Province","grant_id":"ZR2020QB017","title":null},{"funder_name":"Science Foundation of Jiangsu Province","grant_id":"BK20180227","title":null}],"total_grants":8,"fwci":1.761,"citation_percentile":0.84076556,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":9},{"year":2024,"count":7},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1533-3085.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1055/a-1533-3085","host_type":"journal"}],"fields_of_study":["Asymmetric Synthesis and Catalysis","Catalytic C–H Functionalization Methods","Alkaloids: synthesis and pharmacology"],"mesh_terms":[],"keywords":["Stereocenter","Tsuji–Trost reaction","Chemistry","Natural product","Palladium","Alkylation","Combinatorial chemistry","Enantioselective synthesis","Allylic rearrangement","Total synthesis","Catalysis","Stereochemistry","Organic chemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T16:58:20.926942Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}