{"doi":"10.1055/a-1158-0569","title":"Heparin-Coated Liposomes Improve Antiplasmodial Activity and Reduce the Toxicity of Poupartone B","abstract":"Abstract Poupartone B is an alkyl cyclohexenone derivative isolated from Poupartia borbonica. This compound demonstrated promising antimalarial activity (IC50 < 1 µg/mL), however, it was not devoid of toxicity. Thus, to reduce the adverse side effects of this natural bioactive molecule, a delivery strategy involving a nanostructure was formulated. Additionally, poupartone B-loaded liposomes were coated with heparin, a glycosaminoglycan that is known to target proteins on the surface of Plasmodium falciparum-infected red blood cells. The quantification of the compound in the formulation was performed by HPLC-DAD, while heparin was quantitated by 1H NMR spectroscopy. The liposomes’ antiplasmodial activity was tested on artemisinin-resistant P. falciparum isolate, and toxicity was evaluated on human HeLa cells and zebrafish embryos. Throughout this research, the formulation demonstrated higher antiplasmodial activities against both P. falciparum strains and a significant decrease of in vitro toxicity. The formulation improved the selectivity index 2 times in vitro and proved to be 3 times less toxic than the compound alone in the zebrafish embryo acute toxicity test. Hence, the use of this strategy to deliver natural products in Plasmodium-infected cells, particularly those with a narrow therapeutic margin, is proposed.","journal":"Planta Medica International Open","year":2020,"id":89053,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":450973,"name":"Lúcia Mamede","orcid":"0000-0001-8206-8102","position":1,"is_corresponding":false},{"id":452064,"name":"Claudio Palazzo","orcid":null,"position":2,"is_corresponding":false},{"id":450974,"name":"Tania Furst","orcid":"0000-0001-7306-8186","position":3,"is_corresponding":false},{"id":450975,"name":"Olivia Jansen","orcid":"0000-0002-7349-0595","position":4,"is_corresponding":false},{"id":450976,"name":"Pascal De Tullio","orcid":"0000-0003-1416-3858","position":5,"is_corresponding":false},{"id":450977,"name":"Védaste Kagisha","orcid":"0000-0003-2377-8379","position":6,"is_corresponding":false},{"id":452065,"name":"Hélène Pendeville","orcid":null,"position":7,"is_corresponding":false},{"id":309051,"name":"Marianne Fillet","orcid":"0000-0002-1453-6282","position":8,"is_corresponding":false},{"id":450978,"name":"Géraldine Piel","orcid":"0000-0001-8632-4492","position":9,"is_corresponding":false},{"id":450979,"name":"Michel Frédérich","orcid":"0000-0002-0770-9990","position":10,"is_corresponding":false},{"id":450972,"name":"Allison Ledoux","orcid":"0000-0002-4052-6336","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T22:01:50.225871Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}