{"doi":"10.1053/j.seminhematol.2024.11.006","title":"FaMMily Affairs: Dissecting inherited contributions to multiple myeloma risk","abstract":"Etiological links to multiple myeloma (MM) remain poorly understood, though emerging evidence suggests a significant hereditary component. This review integrates current literature on inherited factors contributing to MM risk, synthesizing both epidemiologic and genomic data. We examine familial clustering patterns, assess genome-wide association studies (GWAS) that reveal common genetic variants linked to MM, and explore rare, high-penetrance variants in key susceptibility genes. Additionally, we advocate for routine germline screening in high-risk MM populations, particularly those with a strong family history of cancer, a personal history of cancer, or early-onset disease. By elucidating the inherited influences on MM predisposition, this review seeks to inform future research and refine risk assessment strategies in this population.","journal":"Seminars in Hematology","year":2024,"id":447971,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1233069,"name":"Tehilla Brander","orcid":"0000-0002-2874-7777","position":1,"is_corresponding":false},{"id":1266102,"name":"Julie Gold","orcid":"0000-0003-2993-3536","position":2,"is_corresponding":false},{"id":1266588,"name":"Ayuko Iverson","orcid":null,"position":3,"is_corresponding":false},{"id":50185,"name":"Alessandro Laganà","orcid":"0000-0003-1134-0564","position":4,"is_corresponding":false},{"id":35791,"name":"Kenan Onel","orcid":"0000-0002-2021-6250","position":5,"is_corresponding":false},{"id":25424,"name":"Sundar Jagannath","orcid":"0000-0003-2934-6518","position":6,"is_corresponding":false},{"id":50182,"name":"Samir Parekh","orcid":"0000-0001-9694-8469","position":7,"is_corresponding":false},{"id":50169,"name":"Santiago Thibaud","orcid":"0000-0001-8454-5136","position":8,"is_corresponding":false},{"id":1233067,"name":"Saoirse Bodnar","orcid":"0009-0006-7412-477X","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T02:02:03.354708Z","pmid":"39721861","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}