{"doi":"10.1053/j.jrn.2008.04.010","title":"Long-Term Effect of a Chicken-Based Diet Versus Enalapril on Albuminuria in Type 2 Diabetic Patients With Microalbuminuria","abstract":null,"journal":"Journal of Renal Nutrition","year":2008,"id":608156,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561802,"name":"Themis Zelmanovitz","orcid":null,"position":1,"is_corresponding":false},{"id":1561803,"name":"Mirela J. Azevedo","orcid":null,"position":2,"is_corresponding":false},{"id":1561804,"name":"Tatiana P. de Paula","orcid":null,"position":3,"is_corresponding":false},{"id":1561805,"name":"Jorge L. Gross","orcid":null,"position":4,"is_corresponding":false},{"id":1561801,"name":"Vanessa D.F. de Mello","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long-Term Effect of a Chicken-Based Diet Versus Enalapril on Albuminuria in Type 2 Diabetic Patients With Microalbuminuria","abstract":"<h4>Objective</h4>In short-term studies, the replacement of red meat in the diet with chicken reduced the urinary albumin excretion rate (UAER) and improved lipid profile in type 2 diabetic patients with diabetic nephropathy. The present study sought to assess these effects over a long-term period, comparing the effects of a chicken-based diet (CD) versus enalapril on renal function and lipid profile in microalbuminuric type 2 diabetic patients.<h4>Design</h4>This was a randomized, open-label, controlled clinical trial with a follow-up of 1 year.<h4>Setting</h4>The trial involved outpatients with type 2 diabetes attending a clinic of the Division of Endocrinology at a tertiary-care hospital.<h4>Patients</h4>Twenty-eight microalbuminuric patients completed the study and were evaluated.<h4>Interventions</h4>Patients were randomized to an experimental diet (CD plus active placebo) or to treatment with enalapril (10 mg/day plus usual diet).<h4>Main outcome measures</h4>The main outcome measure was UAER (according to immunoturbidimetry). Blood pressure, anthropometric indices, and compliance were also evaluated monthly. The glomerular filtration rate ((51)Cr-EDTA), and lipid, glycemic, and nutritional indices, were measured at baseline and quarterly.<h4>Results</h4>The UAER was reduced after CD (n = 13; from 62.8 [range, 38.4 to 125.1] to 49.1 [range, 6.2 to 146.5] microg/min; P < .001) and after enalapril (n = 15; from 55.8 [range, 22.6 to 194.3] to 23.1 [range, 4.0 to 104.9] microg/min; P < .001), and this was already significant at month 4. The reduction in UAER after CD (32%; 95% confidence interval, 6.7% to 57.6%) and after enalapril treatment (44.7%; 95% confidence interval, 28.3% to 61.1%; P = .366) were not significantly different.<h4>Conclusions</h4>The CD and the angiotensin-converting enzyme inhibitor enalapril promoted a similar reduction of UAER in patients with type 2 diabetes and microalbuminuria in a 12-month follow-up period.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18721739","pmcid":null,"openalex_id":"https://openalex.org/W2087977053","authors":[],"funders":[],"total_grants":0,"fwci":0.5253,"citation_percentile":0.66967102,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2018,"count":2},{"year":2019,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1051227608002999?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1051227608002999?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1053/j.jrn.2008.04.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18721739","host_type":"repository"}],"fields_of_study":["Chronic Kidney Disease and Diabetes","Veterinary Medicine and Surgery","Sodium Intake and Health","Albuminuria","Angiotensin-Converting Enzyme Inhibitors","Animals","Blood Glucose","Chickens","Combined Modality Therapy","Diabetes Mellitus, Type 2","Diet","Dietary Proteins","Enalapril","Female","Follow-Up Studies","Glomerular Filtration Rate","Humans","Lipids","Male","Meat","Middle Aged","Nutrition Assessment","Treatment Outcome"],"mesh_terms":["Albuminuria","Angiotensin-Converting Enzyme Inhibitors","Animals","Blood Glucose","Chickens","Combined Modality Therapy","Diabetes Mellitus, Type 2","Diet","Dietary Proteins","Enalapril","Female","Follow-Up Studies","Glomerular Filtration Rate","Humans","Lipids","Male","Meat","Middle Aged","Nutrition Assessment","Treatment Outcome"],"keywords":["Microalbuminuria","Medicine","Albuminuria","Enalapril","Term (time)","Internal medicine","Urology","Endocrinology","Diabetes mellitus","Angiotensin-converting enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:35:16.956797Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}