{"doi":"10.1053/j.gastro.2007.05.020","title":"SOX9 Is Required for the Differentiation of Paneth Cells in the Intestinal Epithelium","abstract":"<h4>Background and aims</h4>The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages. In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling.<h4>Methods</h4>To examine the function of SOX9 in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by generating mice that harbored a conditional Sox9 gene and a Villin-Cre transgene.<h4>Results</h4>In the absence of SOX9, Paneth cells were not formed, but the differentiation of other intestinal epithelial cell types was unaffected. The lack of SOX9 also lead to crypt enlargement, to a marked increase in cell proliferation throughout the crypts, and to replacement of the Paneth cells by proliferating epithelial cells.<h4>Conclusions</h4>We conclude that SOX9 is required for the differentiation of Paneth cells. Our results elucidate an essential step in the differentiation of gut epithelium.","journal":"Gastroenterology","year":2007,"id":11139,"datarank":0.8721195797737601,"base_score":5.814130531825066,"endowment":5.814130531825066,"self_citation_contribution":0.8721195797737601,"citation_network_contribution":0.0,"self_endowment_contribution":0.8721195797737601,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":334,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.04,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2007-08-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":15633,"name":"Maaike van den Born","orcid":null,"position":1,"is_corresponding":false},{"id":15636,"name":"Johan H. van Es","orcid":"0000-0002-1338-7078","position":2,"is_corresponding":false},{"id":29240,"name":"Stanley R. Hamilton","orcid":"0000-0002-8331-1052","position":3,"is_corresponding":false},{"id":89941,"name":"Henry P. Adams","orcid":null,"position":4,"is_corresponding":false},{"id":24639,"name":"Jiexin Zhang","orcid":"0000-0001-9526-6730","position":5,"is_corresponding":false},{"id":3646,"name":"Hans Clevers","orcid":"0000-0002-3077-5582","position":6,"is_corresponding":false},{"id":89942,"name":"Benoit de Crombrugghe","orcid":null,"position":7,"is_corresponding":false},{"id":89943,"name":"Benoît De Crombrugghe","orcid":null,"position":8,"is_corresponding":false},{"id":89940,"name":"Yuko Mori–Akiyama","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}