{"doi":"10.1053/j.gastro.2007.03.111","title":"Viremia Profiles in Children With Chronic Hepatitis B Virus Infection and Spontaneous e Antigen Seroconversion","abstract":null,"journal":"Gastroenterology","year":2007,"id":635509,"datarank":0.6535063240034389,"base_score":4.356708826689592,"endowment":4.356708826689592,"self_citation_contribution":0.6535063240034389,"citation_network_contribution":0.0,"self_endowment_contribution":0.6535063240034389,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":77,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1648799,"name":"Mei–Hwei Chang","orcid":null,"position":1,"is_corresponding":false},{"id":1648801,"name":"Pei–Jer Chen","orcid":null,"position":2,"is_corresponding":false},{"id":1648802,"name":"Keh–Sung Tsai","orcid":null,"position":3,"is_corresponding":false},{"id":1648803,"name":"Hong–Yuan Hsu","orcid":null,"position":4,"is_corresponding":false},{"id":1648804,"name":"Huey–Ling Chen","orcid":null,"position":5,"is_corresponding":false},{"id":1648805,"name":"Daw–Jen Tsuei","orcid":null,"position":6,"is_corresponding":false},{"id":1648806,"name":"Ding–Shinn Chen","orcid":null,"position":7,"is_corresponding":false},{"id":1648797,"name":"Yen–Hsuan Ni","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Viremia Profiles in Children With Chronic Hepatitis B Virus Infection and Spontaneous e Antigen Seroconversion","abstract":"<h4>Background & aims</h4>This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous hepatitis B e antigen (HBeAg) seroconversion.<h4>Methods</h4>Fifty-eight children with chronic HBV infection met the following criteria: normal alanine aminotransferase (ALT) level at enrollment, followed up for more than 10 years, no antiviral treatment, and having undergone spontaneous HBeAg seroconversion during follow-up evaluation. They were grouped according to the post-HBeAg seroconversion HBV-DNA levels: (1) low viremia: transient or never 10(4) copies/mL or greater (n=35) (2) fluctuating high viremia: 10(4) copies/mL or greater at least twice at intervals more than 1 year apart (n=23). Abdominal sonography, ALT, and HBV-DNA levels were assessed annually. Another 14 nonseroconverted children served as controls. The precore mutant (nt1896) and genotypes were examined.<h4>Results</h4>The initial HBV-DNA level of the 58 seroconverters was 10(8.4+/-1.0) copies/mL and decreased to 10(2.9+/-2.0) copies/mL at the end of follow-up period. Their mean ages at enrollment, at peak HBV-DNA, at peak ALT, at HBeAg seroconversion, and at final follow-up were 7.0 +/- 3.7, 13.4 +/- 5.8, 16.3 +/- 6.0, 17.2 +/- 5.8, and 23.7 +/- 4.1 years, respectively. The precore mutant appeared more often in the fluctuating-high-viremia group than in the low-viremia group (60.9% vs 22.9%, P=.004). HBV genotypes had no effect on the viremia profiles. After HBeAg seroconversion, none had persistent abnormal ALT levels.<h4>Conclusions</h4>Generally, these young seroconverters had decreased viral loads, normal ALT levels, and uneventful courses after HBeAg seroconversion. A longer follow-up period is necessary to elucidate the significance of HBeAg seroconversion occurring in childhood and young adulthood.","is_dataset_classified":null,"base_score":4.356708826689592,"endowment":4.356708826689592,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17570209","pmcid":null,"openalex_id":"https://openalex.org/W2156839045","authors":[],"funders":[],"total_grants":0,"fwci":4.496,"citation_percentile":0.95012098,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":4},{"year":2014,"count":9},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":3},{"year":2018,"count":2},{"year":2019,"count":5},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"http://www.gastrojournal.org/article/S0016508507006373/pdf","host_type":"journal"},{"url":"http://www.gastrojournal.org/article/S0016508507006373/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0016508507006373?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0016508507006373?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1053/j.gastro.2007.03.111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17570209","host_type":"repository"}],"fields_of_study":["Hepatitis B Virus Studies","Hepatitis C virus research","Hepatitis Viruses Studies and Epidemiology"],"mesh_terms":["Alanine Transaminase","Child","Child, Preschool","DNA, Viral","Female","Follow-Up Studies","Hepatitis B e Antigens","Hepatitis B virus","Humans","Male","Mothers","Mutation","Viremia","Gene Dosage","Viral Load","Hepatitis B, Chronic"],"keywords":["Viremia","Seroconversion","HBeAg","Medicine","Virology","Hepatitis B virus","Immunology","HBsAg","Virus"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:12:39.775579Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}