{"doi":"10.1046/j.1526-4610.2003.03046.x","title":"Familial Occurrence of Migraine With Aura in a Population‐Based Study","abstract":"<jats:p>Objective.—To better define a possible genetic basis for migraine with aura (MWA).</jats:p>\n                  <jats:p>Methods.—We investigated the familial occurrence of migraine with aura in a sample of (MWA) subjects recruited from an epidemiologic study of migraine with aura involving the general population. The sample with migraine with aura (n  =  26) was selected out of a total of 1392 subjects (842 women and 550 men) representative of the general population aged 18 to 65 years in the southern Italian town of San Severo. A family history of migraine with aura was determined via direct interviews with all living first‐degree relatives of the 26 subjects who could be reached by investigators, 119 people: 71 women and 48 men. The diagnosis of migraine with aura was made according to the 1988 International Headache Society (IHS) criteria.</jats:p>\n                  <jats:p>Results.—Of the 26 subjects with migraine with aura, 7 (6 women and 1 man) had a positive family history, with a total of 7 first‐degree relatives affected by the disease (1 mother, 2 fathers, 1 brother, 1 sister, and 2 children). Based on the lifetime prevalence rate of migraine with aura (1.6%) in the San Severo general population, the relative risk of migraine with aura in the first‐degree relatives of the subjects was 3.68 (4.16 for women and 2.77 for men).</jats:p>\n                  <jats:p>Conclusion.—Our subjects' relative risk rate for familial occurrence of migraine with aura was similar to that reported by one investigator, but markedly lower than that reported by another group.</jats:p>","journal":"Headache: The Journal of Head and Face Pain","year":2003,"id":14436,"datarank":1.4328476672041077,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.9441331865008854,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.9441331865008854,"corpus_percentile":61.9,"corpus_rank":480,"citation_count":25,"citer_count":24,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":114020,"name":"A. De Pascale","orcid":null,"position":1,"is_corresponding":false},{"id":114021,"name":"G.C. Manzoni","orcid":null,"position":2,"is_corresponding":false},{"id":114019,"name":"D. Cologno","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12603641","pmcid":null,"openalex_id":"https://openalex.org/W2110645972","authors":[],"funders":[],"total_grants":0,"fwci":1.0598,"citation_percentile":0.75998162,"influential_citations":2,"citation_trend":[{"year":2012,"count":1},{"year":2014,"count":1},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1526-4610.2003.03046.x","host_type":"publisher"},{"url":"https://headachejournal.onlinelibrary.wiley.com/doi/pdf/10.1046/j.1526-4610.2003.03046.x","host_type":"publisher"},{"url":"https://doi.org/10.1046/j.1526-4610.2003.03046.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12603641","host_type":"repository"}],"fields_of_study":["Migraine and Headache Studies","Neurological Complications and Syndromes","Cerebrovascular and genetic disorders","Medicine","Adolescent","Adult","Aged","Family Health","Female","Humans","Italy","Male","Middle Aged","Migraine with Aura","Pedigree","Prevalence","Risk Factors"],"mesh_terms":["Adolescent","Adult","Aged","Family Health","Female","Humans","Italy","Male","Middle Aged","Pedigree","Risk Factors","Prevalence","Migraine with Aura"],"keywords":["Aura","Migraine","Migraine with aura","Medicine","Family aggregation","Population","First-degree relatives","Family history","Familial hemiplegic migraine","Psychiatry","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-01T10:01:52.069712Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}