{"doi":"10.1046/j.1468-2982.2002.00363.x","title":"A Quantification of the Placebo Response in Migraine Prophylaxis","abstract":"<jats:p>To quantify the placebo response of prophylactic therapy in migraine, a meta-analysis of prophylactic, double-blind, placebo controlled migraine studies was performed. The total analysis included 22 studies testing 19 different products, including 2013 patients, of which 828 were treated with placebo. A reduction in migraine attacks of 50% or more (responders) was seen in 23.5% ± 8.0 (95% C.I. 18.3-28.8%) of the patients in the placebo groups and 45.5% ± 15.5 (95% C.I. 37.4-53.6%) in the active groups. A reduction in migraine attacks of 16.8% ± 12.7 (95% C.I. 10.9-22.6%) was observed in the placebo groups and 41.8% ± 11.7 (95% C.I. 36.9-46.6%) in the active groups. We propose that if the percentage of responders in an open-label prophylactic trial in migraine is above 35-40%, or if a reduction in migraine attack frequency is found of 40% or more, further studies are indicated to determine the prophylactic activity of the drug. In all studies included in this analysis, no placebo response was seen above these limits.</jats:p>","journal":"Cephalalgia","year":2002,"id":32133,"datarank":10.44992749835145,"base_score":4.553876891600541,"endowment":4.553876891600541,"self_citation_contribution":0.6830815337400812,"citation_network_contribution":9.766845964611369,"self_endowment_contribution":0.6830815337400812,"citer_contribution":9.766845964611369,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":94,"citers_with_citation_signal":80,"citers_with_endowment":80,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":170701,"name":"JJHM Lohman","orcid":null,"position":1,"is_corresponding":false},{"id":170700,"name":"P-HM van der Kuy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.553876891600541,"endowment":4.553876891600541,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12100088","pmcid":null,"openalex_id":"https://openalex.org/W2167297145","authors":[],"funders":[],"total_grants":0,"fwci":3.0297,"citation_percentile":0.91221819,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":1},{"year":2015,"count":3},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1046/j.1468-2982.2002.00363.x","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1046/j.1468-2982.2002.00363.x","host_type":"publisher"},{"url":"https://doi.org/10.1046/j.1468-2982.2002.00363.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12100088","host_type":"repository"}],"fields_of_study":["Migraine and Headache Studies","Psychosomatic Disorders and Their Treatments","Body Image and Dysmorphia Studies","Medicine","Analgesics, Non-Narcotic","Cross-Over Studies","Double-Blind Method","Humans","Migraine Disorders","Placebo Effect","Placebos","Randomized Controlled Trials as Topic","Treatment Outcome"],"mesh_terms":["Double-Blind Method","Humans","Migraine Disorders","Placebos","Placebo Effect","Randomized Controlled Trials as Topic","Treatment Outcome","Cross-Over Studies","Analgesics, Non-Narcotic"],"keywords":["Migraine","Placebo","Medicine","Prophylactic treatment","Placebo response","Placebo group","Anesthesia","Internal medicine","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T10:37:52.800998Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}