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Such speculations gain preliminary support from the effects of excitotoxic lesions that preferentially, but not selectively, target the noncholinergic component of the basal forebrain corticopetal system, on performance in tasks involving demands on cognitive flexibility. Progress in understanding the cognitive functions of the basal forebrain system depends on evidence regarding its main noncholinergic components, and the generation of such evidence is contingent on the development of methods to manipulate and monitor selectively the activity of the GABAergic corticopetal projections.</jats:p>","journal":"European Journal of Neuroscience","year":2002,"id":672829,"datarank":0.7117398192544876,"base_score":4.74493212836325,"endowment":4.74493212836325,"self_citation_contribution":0.7117398192544876,"citation_network_contribution":0.0,"self_endowment_contribution":0.7117398192544876,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":114,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":975950,"name":"John P. 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The possibility that basal forebrain GABAergic neurons that project to the cortex are selectively contacted by corticofugal projections suggests that the functions of the GABAergic branch can be conceptualized in terms of mediating executive aspects of cognitive performance, including the switching between multiple input sources and response rules. Such speculations gain preliminary support from the effects of excitotoxic lesions that preferentially, but not selectively, target the noncholinergic component of the basal forebrain corticopetal system, on performance in tasks involving demands on cognitive flexibility. Progress in understanding the cognitive functions of the basal forebrain system depends on evidence regarding its main noncholinergic components, and the generation of such evidence is contingent on the development of methods to manipulate and monitor selectively the activity of the GABAergic corticopetal projections.</jats:p>","is_dataset_classified":null,"base_score":4.74493212836325,"endowment":4.74493212836325,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12099892","pmcid":null,"openalex_id":"https://openalex.org/W2077717121","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"AG10173","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"MH57436","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"NS37026","title":null}],"total_grants":3,"fwci":3.0651,"citation_percentile":0.91072105,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":4},{"year":2014,"count":5},{"year":2015,"count":8},{"year":2016,"count":4},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":6},{"year":2024,"count":6},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1460-9568.2002.02004.x","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1460-9568.2002.02004.x","host_type":"publisher"},{"url":"https://doi.org/10.1046/j.1460-9568.2002.02004.x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12099892","host_type":"repository"}],"fields_of_study":["Memory and Neural Mechanisms","Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","Animals","Cholinergic Fibers","Cognition","Globus Pallidus","Humans","Learning","Neural Pathways","Neurons","Prefrontal Cortex","Septal Nuclei","Substantia Innominata","gamma-Aminobutyric Acid"],"mesh_terms":["Animals","Cholinergic Fibers","Cognition","gamma-Aminobutyric Acid","Globus Pallidus","Humans","Learning","Neural Pathways","Neurons","Septal Nuclei","Substantia Innominata","Prefrontal Cortex"],"keywords":["Basal forebrain","GABAergic","Neuroscience","Forebrain","Cholinergic","Cholinergic neuron","Cognition","Cortex (anatomy)","Psychology","Biology","Central nervous system","Inhibitory postsynaptic potential"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T11:14:19.570772Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}