{"doi":"10.1042/etls20230081","title":"Learning the mechanobiology of development from gastruloids","abstract":"<jats:p>Gastruloids acquire their organization and shape through cell biochemical and mechanical activities. Such activities determine the physical forces and changes in material properties that transform simple spherical aggregates into organized tissues. In this Perspective, we discuss why the concepts and approaches of mechanobiology, a discipline that focuses on cell and tissue mechanics and its contribution to the organization and functions of living systems, are essential to the gastruloid field and, in turn, what gastruloids may teach us about mechanobiology.</jats:p>","journal":"Emerging Topics in Life Sciences","year":2023,"id":616508,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":309250,"name":"Sham Tlili","orcid":"0000-0001-6018-9923","position":1,"is_corresponding":false},{"id":309230,"name":"Pierre‐François Lenne","orcid":"0000-0003-1066-7506","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Learning the mechanobiology of development from gastruloids","abstract":"<jats:p>Gastruloids acquire their organization and shape through cell biochemical and mechanical activities. Such activities determine the physical forces and changes in material properties that transform simple spherical aggregates into organized tissues. In this Perspective, we discuss why the concepts and approaches of mechanobiology, a discipline that focuses on cell and tissue mechanics and its contribution to the organization and functions of living systems, are essential to the gastruloid field and, in turn, what gastruloids may teach us about mechanobiology.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38054574","pmcid":null,"openalex_id":"https://openalex.org/W4389387458","authors":[],"funders":[{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-19-CE13-0022","title":"Integration of biochemical and mechanical signals at cell adhesive contacts during mammalian morphogenesis: a quantitative approach using a minimal self-organized system"}],"total_grants":1,"fwci":0.6539,"citation_percentile":0.64186658,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://amu.hal.science/hal-04430839/document","host_type":"repository"},{"url":"https://amu.hal.science/hal-04430839/document","host_type":"repository"},{"url":"https://portlandpress.com/emergtoplifesci/article-pdf/7/4/417/952677/etls-2023-0081c.pdf","host_type":"publisher"},{"url":"https://amu.hal.science/hal-04430839","host_type":"repository"},{"url":"https://doi.org/10.1042/etls20230081","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38054574","host_type":"repository"},{"url":"https://amu.hal.science/hal-04430839v1/document","host_type":""},{"url":"https://amu.hal.science/hal-04430839v1","host_type":""}],"fields_of_study":["Cellular Mechanics and Interactions","Microtubule and mitosis dynamics","Caveolin-1 and cellular processes","0301 basic medicine","03 medical and health sciences","Biophysics","Embryonic Stem Cells"],"mesh_terms":["Biophysics","Embryonic Stem Cells"],"keywords":["Mechanobiology","Perspective (graphical)","Cell mechanics","Simple (philosophy)","Field (mathematics)","Computer science","Nanotechnology","Cognitive science","Chemistry","Cell","Biology","Materials science","Psychology","Epistemology","Cell biology","Artificial intelligence","Mathematics","Morphogenesis","Patterning","Mechanotransduction","[SDV] Life Sciences [q-bio]","Biophysics","Embryonic Stem Cells"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T23:03:54.263779Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}