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This elusive pathway appears clearly distinct from that of the widely prescribed statins that also enhance LDLR function but do not lower circulating Lp (a) levels in humans. So how does PCSK9 inhibition with mAbs reduce Lp(a)? This still remains to be established.</jats:p>","journal":"Clinical Science","year":2017,"id":636290,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1651316,"name":"Aurélie Thedrez","orcid":null,"position":1,"is_corresponding":false},{"id":1469968,"name":"Mikaël Croyal","orcid":"0000-0002-5449-5817","position":2,"is_corresponding":false},{"id":1651318,"name":"Stéphane Ramin-Mangata","orcid":null,"position":3,"is_corresponding":false},{"id":1550778,"name":"David Couret","orcid":null,"position":4,"is_corresponding":false},{"id":1596971,"name":"Nicolas Diotel","orcid":"0000-0003-2032-518X","position":5,"is_corresponding":false},{"id":1651321,"name":"Estelle Nobécourt-Dupuy","orcid":null,"position":6,"is_corresponding":false},{"id":1651323,"name":"Michel Krempf","orcid":null,"position":7,"is_corresponding":false},{"id":1651326,"name":"Jean Christophe LeBail","orcid":null,"position":8,"is_corresponding":false},{"id":1651328,"name":"Bruno Poirier","orcid":null,"position":9,"is_corresponding":false},{"id":1651329,"name":"Jorg Blankenstein","orcid":null,"position":10,"is_corresponding":false},{"id":1651330,"name":"Elise F. 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More recent investigations, either in vitro or in vivo, have attempted to unravel the mechanism(s) by which PCSK9 mAbs reduce circulating Lp(a) levels, with some showing a specific implication of the LDL receptor (LDLR) in Lp(a) clearance whereas others found no significant role for the LDLR in that process. This elusive pathway appears clearly distinct from that of the widely prescribed statins that also enhance LDLR function but do not lower circulating Lp (a) levels in humans. So how does PCSK9 inhibition with mAbs reduce Lp(a)? 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