{"doi":"10.1042/cs0650009","title":"Effects of Acute Blood Volume Expansion on Vascular Resistance and Reactivity in Anaesthetized Dogs","abstract":"<jats:p>1. The effects of acute volume expansion on vascular resistance and reactivity to noradrenaline and angiotensin II are reported in this study. The estimated circulating blood volume of pentobartibal-anaesthetized dogs was expanded by about 35% with equilibrated donor blood. The animals were bilaterally nephrectomized to sustain expanded volume.</jats:p>\n               <jats:p>2. Functional changes in vascular smooth muscle were determined in the flow controlled, vascularly isolated, denervated, perfused hind limb preparation in the same animal.</jats:p>\n               <jats:p>3. Systemic volume expansion per se had no immediate influence on vascular resistance. However, resistance in the hind limb, as determined by the shift of the pressure-flow curves, progressively increased 60 and 120 min after volume expansion. The changes noted after 120 min were significantly greater than those observed after 60 min.</jats:p>\n               <jats:p>4. The changes in vascular resistance were accompanied by potentiation of the vascular responses to noradrenaline but not to angiotensin II. Significant shifts which occurred in the noradrenaline dose-response curves were similar to those of the resistance curves.</jats:p>\n               <jats:p>5. in closely simulated control experiments in dogs whose kidneys were intact or had been removed, and whose blood had or had not been equilibrated with donor blood, the above-mentioned vascular changes were not observed in the absence of volume expansion.</jats:p>\n               <jats:p>6. It is suggested that the functional changes observed in the hind limb vasculature after volume expansion are related to the presence of a circulating substance. From the data obtained from the experimental model used in this study, it can be concluded that such a substance is not released from the kidney.</jats:p>","journal":"Clinical Science","year":1983,"id":662642,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1729945,"name":"Gary J. Hom","orcid":null,"position":1,"is_corresponding":false},{"id":1729944,"name":"Bhagavan S. Jandhyala","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of Acute Blood Volume Expansion on Vascular Resistance and Reactivity in Anaesthetized Dogs","abstract":"<jats:p>1. The effects of acute volume expansion on vascular resistance and reactivity to noradrenaline and angiotensin II are reported in this study. The estimated circulating blood volume of pentobartibal-anaesthetized dogs was expanded by about 35% with equilibrated donor blood. The animals were bilaterally nephrectomized to sustain expanded volume.</jats:p>\n               <jats:p>2. Functional changes in vascular smooth muscle were determined in the flow controlled, vascularly isolated, denervated, perfused hind limb preparation in the same animal.</jats:p>\n               <jats:p>3. Systemic volume expansion per se had no immediate influence on vascular resistance. However, resistance in the hind limb, as determined by the shift of the pressure-flow curves, progressively increased 60 and 120 min after volume expansion. The changes noted after 120 min were significantly greater than those observed after 60 min.</jats:p>\n               <jats:p>4. The changes in vascular resistance were accompanied by potentiation of the vascular responses to noradrenaline but not to angiotensin II. Significant shifts which occurred in the noradrenaline dose-response curves were similar to those of the resistance curves.</jats:p>\n               <jats:p>5. in closely simulated control experiments in dogs whose kidneys were intact or had been removed, and whose blood had or had not been equilibrated with donor blood, the above-mentioned vascular changes were not observed in the absence of volume expansion.</jats:p>\n               <jats:p>6. It is suggested that the functional changes observed in the hind limb vasculature after volume expansion are related to the presence of a circulating substance. From the data obtained from the experimental model used in this study, it can be concluded that such a substance is not released from the kidney.</jats:p>","is_dataset_classified":null,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6851422","pmcid":null,"openalex_id":"https://openalex.org/W2336579455","authors":[],"funders":[],"total_grants":0,"fwci":5.5543,"citation_percentile":0.96382637,"influential_citations":0,"citation_trend":[{"year":2016,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://portlandpress.com/clinsci/article-pdf/65/1/9/454193/cs0650009.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/cs0650009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6851422","host_type":"repository"}],"fields_of_study":["Veterinary Pharmacology and Anesthesia","Muscle metabolism and nutrition","Hemodynamic Monitoring and Therapy"],"mesh_terms":["Angiotensin II","Animals","Blood Pressure","Blood Transfusion","Blood Volume","Dogs","Dose-Response Relationship, Drug","Female","Heart Rate","Male","Norepinephrine","Perfusion","Vascular Resistance"],"keywords":["Vascular resistance","Hindlimb","Blood volume","Blood flow","Volume (thermodynamics)","Internal medicine","Volume expansion","Chemistry","Blood vessel","Hemodynamics","Blood pressure","Vascular smooth muscle","Endocrinology","Angiotensin II","Fissipedia","Medicine","Smooth muscle"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T16:39:23.113216Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}