{"doi":"10.1042/cs0390591","title":"Protein Turnover in Skeletal Muscle. II. The Effect of Starvation and a Protein-Free Diet on the Synthesis and Catabolism of Skeletal Muscle Proteins in Comparison to Liver","abstract":"<jats:p>1. Rates of synthesis and catabolism of liver and muscle sarcoplasmic and myofibrillar protein have been measured in young control, starved and protein (deprived) rats using [14C]Na2CO3 to label protein.</jats:p>\n               <jats:p>2. Half-lives for synthesis of 1·35, 2·8 and 7·2 days for liver, sarcoplasmic and myofibrillar proteins respectively were obtained, whilst half-lives for catabolism were 1·55, 3·6 and 15·6 days in each case in the control animals.</jats:p>\n               <jats:p>3. The protein free diet for 3 days caused a small decrease in the rate of synthesis of liver and muscle proteins. The catabolic rate of liver protein was increased by 20% whilst there was a smaller increase in the catabolic rate of myofibrillar proteins.</jats:p>\n               <jats:p>4. Starvation for 3 days caused a 20% reduction in the rate of liver protein synthesis whilst there were greater reductions in muscle protein synthesis. The catabolic rate of liver protein was only slightly increased whereas there was a 75% increase in the rate of myofibrillar protein breakdown.</jats:p>\n               <jats:p>5. The total amount of protein synthesis and catabolism in liver and the two muscle protein fractions over the first 3 days of the three regimes were calculated. Muscle protein turnover, in particular myofibrillar, was shown to be very sensitive to dietary protein and/or calorie deficiency.</jats:p>\n               <jats:p>6. These results are discussed in terms of the mobility and therefore importance of muscle protein metabolism in the economy of the whole animal.</jats:p>","journal":"Clinical Science","year":1970,"id":36760,"datarank":11.233319399027435,"base_score":4.997212273764115,"endowment":4.997212273764115,"self_citation_contribution":0.7495818410646173,"citation_network_contribution":10.483737557962817,"self_endowment_contribution":0.7495818410646173,"citer_contribution":10.483737557962817,"corpus_percentile":null,"corpus_rank":null,"citation_count":147,"citer_count":131,"citers_with_citation_signal":122,"citers_with_endowment":122,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":185585,"name":"D. J. Millward","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.997212273764115,"endowment":4.997212273764115,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"5493535","pmcid":null,"openalex_id":"https://openalex.org/W1578211856","authors":[],"funders":[],"total_grants":0,"fwci":6.8547,"citation_percentile":0.97211711,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://portlandpress.com/clinsci/article-pdf/39/5/591/738074/cs0390591.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/cs0390591","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/5493535","host_type":"repository"}],"fields_of_study":["Muscle metabolism and nutrition","Animal Nutrition and Physiology","Metabolism and Genetic Disorders","Animals","Blood Proteins","Carbon Isotopes","Carbonates","Diet","Dietary Proteins","Liver","Muscle Proteins","Muscles","Myofibrils","Organ Size","Protein Deficiency","Rats","Starvation"],"mesh_terms":["Animals","Blood Proteins","Carbon Isotopes","Carbonates","Diet","Dietary Proteins","Liver","Muscle Proteins","Muscles","Myofibrils","Organ Size","Protein Deficiency","Starvation","Rats"],"keywords":["Catabolism","Myofibril","Protein catabolism","Sarcoplasm","Protein turnover","Skeletal muscle","Protein degradation","Internal medicine","Protein biosynthesis","Endocrinology","Biology","Protein metabolism","Muscle protein","Biochemistry","Starvation","Metabolism","Chemistry","Endoplasmic reticulum","Amino acid","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T17:19:06.146397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}