{"doi":"10.1042/bst20190008","title":"One-carbon metabolism in cancer cells: a critical review based on a core model of central metabolism","abstract":"<jats:p>One-carbon metabolism (1C-metabolism), also called folate metabolism because the carbon group is attached to folate-derived tetrahydrofolate, is crucial in metabolism. It is at the heart of several essential syntheses, particularly those of purine and thymidylate. After a short reminder of the organization of 1C-metabolism, I list its salient features as reported in the literature. Then, using flux balance analysis, a core model of central metabolism and the flux constraints for an ‘average cancer cell metabolism’, I explore the fundamentals underlying 1C-metabolism and its relationships with the rest of metabolism. Some unreported properties of 1C-metabolism emerge, such as its potential roles in mitochondrial NADH exchange with cytosolic NADPH, participation in NADH recycling, and optimization of cell proliferation.</jats:p>","journal":"Biochemical Society Transactions","year":2021,"id":661832,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1727788,"name":"Jean-Pierre Mazat","orcid":"0000-0002-7832-7455","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"One-carbon metabolism in cancer cells: a critical review based on a core model of central metabolism","abstract":"<jats:p>One-carbon metabolism (1C-metabolism), also called folate metabolism because the carbon group is attached to folate-derived tetrahydrofolate, is crucial in metabolism. It is at the heart of several essential syntheses, particularly those of purine and thymidylate. After a short reminder of the organization of 1C-metabolism, I list its salient features as reported in the literature. Then, using flux balance analysis, a core model of central metabolism and the flux constraints for an ‘average cancer cell metabolism’, I explore the fundamentals underlying 1C-metabolism and its relationships with the rest of metabolism. Some unreported properties of 1C-metabolism emerge, such as its potential roles in mitochondrial NADH exchange with cytosolic NADPH, participation in NADH recycling, and optimization of cell proliferation.</jats:p>","is_dataset_classified":null,"base_score":2.833213344056216,"endowment":2.833213344056216,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33616629","pmcid":null,"openalex_id":"https://openalex.org/W3129309980","authors":[],"funders":[],"total_grants":0,"fwci":0.7103,"citation_percentile":0.6089021,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://portlandpress.com/biochemsoctrans/article-pdf/49/1/1/905010/bst-2019-0008c.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/bst20190008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33616629","host_type":"repository"},{"url":"https://cnrs.hal.science/hal-04833279","host_type":"repository"}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Folate and B Vitamins Research","Biochemical and Molecular Research","Animals","Biochemical Phenomena","Carbon","Energy Metabolism","Humans","Mitochondria","Neoplasms","Neoplastic Stem Cells"],"mesh_terms":["Animals","Biochemical Phenomena","Carbon","Energy Metabolism","Humans","Mitochondria","Neoplasms","Neoplastic Stem Cells"],"keywords":["Metabolism","Biochemistry","Purine metabolism","Flux (metallurgy)","Carbon flux","Cell metabolism","Chemistry","Biology","Enzyme","Flux Balance Analysis","One-carbon Metabolism","Metabolic Model","Average Cancer Cell","Cancer Cells’ Metabolism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T11:43:33.418534Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}