{"doi":"10.1042/bsr20170682","title":"Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of <i>miR-200b/a/429</i>","abstract":"<jats:p>Long noncoding RNAs (lncRNAs) are frequently dysregulated and have important roles in many diseases, particularly cancers. lncRNA-HEIH was first identified in hepatocellular carcinoma (HCC). The expression, clinical significance and roles of lncRNA-HEIH in melanoma are still unknown. In the present study, we found that lncRNA-HEIH is highly expressed in melanoma tissues and cell lines, associated with advanced clinical stages, and predicts poor outcomes in melanoma patients. Functional assays showed that ectopic expression of lncRNA-HEIH promotes melanoma cell proliferation, migration and invasion. Knockdown of lncRNA-HEIH inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we revealed that lncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription. The expression of miR-200b is inversely associated with lncRNA-HEIH in melanoma tissues. Furthermore, overexpression of miR-200b/a/429 abrogates melanoma cell proliferation, migration and invasion enhanced by lncRNA-HEIH. In conclusion, we identified lncRNA-HEIH as a key oncogene in melanoma via transcriptional inhibition of miR-200b/a/429. Our data suggested that lncRNA-HEIH may serve as a promising prognostic biomarker and therapeutic target for melanoma.</jats:p>","journal":"Bioscience Reports","year":2017,"id":626158,"datarank":0.6141516843333151,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.0,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1619620,"name":"Guoping Xing","orcid":null,"position":1,"is_corresponding":false},{"id":1262226,"name":"Yingying Wang","orcid":"0000-0002-3659-6139","position":2,"is_corresponding":false},{"id":1619621,"name":"Zengxiang Luo","orcid":null,"position":3,"is_corresponding":false},{"id":1484004,"name":"Guoyan Liu","orcid":"0000-0003-4429-6336","position":4,"is_corresponding":false},{"id":1619622,"name":"Huijuan Meng","orcid":null,"position":5,"is_corresponding":false},{"id":1558911,"name":"Haiying Zhao","orcid":"0000-0001-6587-5252","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Long noncoding RNA HEIH promotes melanoma cell proliferation, migration and invasion via inhibition of <i>miR-200b/a/429</i>","abstract":"<jats:p>Long noncoding RNAs (lncRNAs) are frequently dysregulated and have important roles in many diseases, particularly cancers. lncRNA-HEIH was first identified in hepatocellular carcinoma (HCC). The expression, clinical significance and roles of lncRNA-HEIH in melanoma are still unknown. In the present study, we found that lncRNA-HEIH is highly expressed in melanoma tissues and cell lines, associated with advanced clinical stages, and predicts poor outcomes in melanoma patients. Functional assays showed that ectopic expression of lncRNA-HEIH promotes melanoma cell proliferation, migration and invasion. Knockdown of lncRNA-HEIH inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we revealed that lncRNA-HEIH directly binds to miR-200b/a/429 promoter and represses miR-200b/a/429 transcription. The expression of miR-200b is inversely associated with lncRNA-HEIH in melanoma tissues. Furthermore, overexpression of miR-200b/a/429 abrogates melanoma cell proliferation, migration and invasion enhanced by lncRNA-HEIH. In conclusion, we identified lncRNA-HEIH as a key oncogene in melanoma via transcriptional inhibition of miR-200b/a/429. Our data suggested that lncRNA-HEIH may serve as a promising prognostic biomarker and therapeutic target for melanoma.</jats:p>","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28487474","pmcid":"PMC5479024","openalex_id":"https://openalex.org/W2613842309","authors":[],"funders":[],"total_grants":0,"fwci":3.3312,"citation_percentile":0.93241086,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":13},{"year":2020,"count":17},{"year":2021,"count":9},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://portlandpress.com/bioscirep/article-pdf/37/3/BSR20170682/431003/bsr-2017-0682.pdf","host_type":"journal"},{"url":"https://portlandpress.com/bioscirep/article-pdf/37/3/BSR20170682/431003/bsr-2017-0682.pdf","host_type":"publisher"},{"url":"https://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20170682/431003/bsr-2017-0682.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/bsr20170682","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28487474","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC5479024","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5479024","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5479024","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5479024?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer-related molecular mechanisms research","Circular RNAs in diseases","RNA regulation and disease","Biomarkers, Tumor","Cell Line, Tumor","Cell Movement","Cell Proliferation","Down-Regulation","Gene Expression Regulation, Neoplastic","Humans","Kaplan-Meier Estimate","Melanocytes","Melanoma","MicroRNAs","Neoplasm Invasiveness","Promoter Regions, Genetic","RNA, Long Noncoding","Skin Neoplasms","Treatment Outcome"],"mesh_terms":["Cell Movement","Humans","Melanocytes","Melanoma","Neoplasm Invasiveness","Promoter Regions, Genetic","Skin Neoplasms","Biomarkers, Tumor","Down-Regulation","Gene Expression Regulation, Neoplastic","Treatment Outcome","MicroRNAs","Cell Line, Tumor","Cell Proliferation","Kaplan-Meier Estimate","RNA, Long Noncoding"],"keywords":["Long non-coding RNA","microRNA","RNA","Cell growth","Cell biology","Cancer research","Melanoma","Non-coding RNA","Biology","Genetics","Gene","Cell proliferation","cell invasion","cell migration","Mir-200","Long Noncoding Rna"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"No poverty"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T12:41:00.077818Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}