{"doi":"10.1042/bj2170471","title":"Effect of a protein-free diet on muscle protein turnover and nitrogen conservation in euthyroid and hyperthyroid rats","abstract":"<jats:p>Although protein turnover in skeletal muscle is increased in hyperthyroidism and decreased in hypothyroidism, a deficient protein intake tends to increase serum T3 (tri-iodothyronine) while decreasing muscle protein turnover. To determine whether this diet-induced decrease in protein turnover can occur independent of thyroid status, we have examined muscle protein turnover and nitrogen conservation in hyperthyroid rats fed on a protein-free diet. After inducing hyperthyroidism by giving 20 micrograms of T3/100g body wt. daily for 7 days, groups of euthyroid and hyperthyroid animals were divided into subgroups fed on basal and protein-free diets. Muscle protein turnover was measured by N tau-methylhistidine excretion and [14C]tyrosine infusion. Urinary nitrogen output of euthyroid and hyperthyroid animals fed on the protein-free diet was also measured. Although hyperthyroidism increased the baseline rates of muscle protein synthesis and degradation, it did not prevent a decrease in these values in response to protein depletion. Furthermore, hyperthyroid rats showed greatly decreased nitrogen excretion in response to the protein-free diet, although not to values for euthyroid rats. These findings suggest that protein depletion made the experimental animals less responsive to the protein-catabolic effects of T3.</jats:p>","journal":"Biochemical Journal","year":1984,"id":40568,"datarank":0.7743782730229846,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.40164227555478443,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.40164227555478443,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":196891,"name":"W S van der Weijden Benjamin","orcid":null,"position":1,"is_corresponding":false},{"id":196892,"name":"F H Faas","orcid":null,"position":2,"is_corresponding":false},{"id":196890,"name":"W J Carter","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6696742","pmcid":"PMC1153238","openalex_id":"https://openalex.org/W88791625","authors":[],"funders":[{"funder_name":"NIADDK NIH HHS","grant_id":"AM20718-05","title":null}],"total_grants":1,"fwci":0.3051,"citation_percentile":0.49213144,"influential_citations":0,"citation_trend":[{"year":2013,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://portlandpress.com/biochemj/article-pdf/217/2/471/579889/bj2170471.pdf","host_type":"journal"},{"url":"https://europepmc.org/articles/pmc1153238?pdf=render","host_type":"GREEN"},{"url":"https://portlandpress.com/biochemj/article-pdf/217/2/471/579889/bj2170471.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/bj2170471","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6696742","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1153238","host_type":"repository"}],"fields_of_study":["Thyroid Disorders and Treatments","Growth Hormone and Insulin-like Growth Factors","Muscle metabolism and nutrition","Medicine","Chemistry","Biology","Animals","Hyperthyroidism","Male","Methylhistidines","Muscle Proteins","Nitrogen","Protein Deficiency","Rats","Rats, Inbred Strains","Triiodothyronine","Tyrosine"],"mesh_terms":["Animals","Hyperthyroidism","Male","Methylhistidines","Muscle Proteins","Nitrogen","Protein Deficiency","Rats, Inbred Strains","Triiodothyronine","Tyrosine","Rats"],"keywords":["Euthyroid","Protein turnover","Internal medicine","Endocrinology","Protein catabolism","Excretion","Protein metabolism","Catabolism","Protein degradation","Nitrogen balance","Skeletal muscle","Thyroid","Turnover","Muscle protein","Metabolism","Basal (medicine)","Biology","Chemistry","Medicine","Amino acid","Protein biosynthesis","Nitrogen","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T07:31:20.492130Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}