{"doi":"10.1042/bj2140937","title":"Development and regulation of ketogenesis in hepatocytes isolated from newborn rats","abstract":"<jats:p>The development of fatty acid metabolism was studied in isolated hepatocytes from newborn rats. Ketone-body production from oleate is increased 6-fold between 0 and 16 h after birth. This increase is related to an enhanced beta-oxidation rather than to a channeling of acetyl-CoA from the tricarboxylic acid cycle to ketone-body synthesis. The increase in oleate oxidation is not related to a decreased esterification rate, as the latter is already low at birth and does not decrease further. At birth, lipogenic rate is 2-3-fold lower than in fed adult rats and it decreases to undetectable values in 16 h-old rats. A 90% inhibition of lipogenesis in hepatocytes of newborn rats (0 h) by glucagon and 5-(tetradecyloxy)-2-furoic acid does not lead to an increased oxidation of non-esterified fatty acids. This suggests that the inverse relationship between lipogenesis and ketogenesis in the starved newborn rat is not responsible for the switch-on of fatty acid oxidation at birth. Moreover, ketogenesis from octanoate, a medium-chain fatty acid the oxidation of which is independent of carnitine acyltransferase, follows the same developmental pattern at birth as that from oleate.</jats:p>","journal":"Biochemical Journal","year":1983,"id":652257,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1701413,"name":"P Satabin","orcid":null,"position":1,"is_corresponding":false},{"id":1701414,"name":"J F Decaux","orcid":null,"position":2,"is_corresponding":false},{"id":1701415,"name":"F Escriva","orcid":null,"position":3,"is_corresponding":false},{"id":965473,"name":"J Girard","orcid":null,"position":4,"is_corresponding":false},{"id":1701412,"name":"P Ferré","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Development and regulation of ketogenesis in hepatocytes isolated from newborn rats","abstract":"<jats:p>The development of fatty acid metabolism was studied in isolated hepatocytes from newborn rats. Ketone-body production from oleate is increased 6-fold between 0 and 16 h after birth. This increase is related to an enhanced beta-oxidation rather than to a channeling of acetyl-CoA from the tricarboxylic acid cycle to ketone-body synthesis. The increase in oleate oxidation is not related to a decreased esterification rate, as the latter is already low at birth and does not decrease further. At birth, lipogenic rate is 2-3-fold lower than in fed adult rats and it decreases to undetectable values in 16 h-old rats. A 90% inhibition of lipogenesis in hepatocytes of newborn rats (0 h) by glucagon and 5-(tetradecyloxy)-2-furoic acid does not lead to an increased oxidation of non-esterified fatty acids. This suggests that the inverse relationship between lipogenesis and ketogenesis in the starved newborn rat is not responsible for the switch-on of fatty acid oxidation at birth. Moreover, ketogenesis from octanoate, a medium-chain fatty acid the oxidation of which is independent of carnitine acyltransferase, follows the same developmental pattern at birth as that from oleate.</jats:p>","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6626164","pmcid":"PMC1152335","openalex_id":"https://openalex.org/W296277486","authors":[],"funders":[],"total_grants":0,"fwci":3.6446,"citation_percentile":0.92705141,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1152335","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1152335","host_type":"repository"},{"url":"https://portlandpress.com/biochemj/article-pdf/214/3/937/580411/bj2140937.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1042/bj2140937","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6626164","host_type":"repository"},{"url":"https://hal.science/hal-03082155","host_type":"repository"}],"fields_of_study":["Diet and metabolism studies","Metabolism and Genetic Disorders","Adipose Tissue and Metabolism","Animals","Animals, Newborn","Caprylates","Female","In Vitro Techniques","Ketone Bodies","Lactates","Lactic Acid","Lipids","Liver","Oleic Acid","Oleic Acids","Rats","Rats, Inbred Strains"],"mesh_terms":["Animals","Animals, Newborn","Caprylates","Female","Ketone Bodies","Lactates","Lipids","Liver","Oleic Acids","Rats, Inbred Strains","Oleic Acid","Lactic Acid","Rats","In Vitro Techniques"],"keywords":["Ketogenesis","Lipogenesis","Ketone bodies","Beta oxidation","Internal medicine","Endocrinology","Fatty acid","Chemistry","Metabolism","Biochemistry","Carnitine","Gluconeogenesis","Glycerol","Biology","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T12:42:24.798085Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}