{"doi":"10.1039/d5sc05710h","title":"Ultrasound-triggered prodrug activation <i>via</i> sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold","abstract":". Remarkably, this sonochemical activation was successfully achieved through 2 cm of chicken breast, highlighting the deep-penetrating capability of our approach. Extending this strategy, we developed ProR848, a sono-activable prodrug of the Toll-like receptors (TLR) agonist R848, enabling remotely triggered, on-demand immune cell activation. Collectively, our results establish a novel and versatile sonochemical cleavage platform for ultrasound-targeted prodrug activation, offering significant potential for applications including controlled therapeutic release and responsive biomaterials.","journal":"Chemical Science","year":2025,"id":514532,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1377172,"name":"Bowen Xu","orcid":"0009-0000-7828-8161","position":1,"is_corresponding":false},{"id":1377785,"name":"H.D. Sarath Liyanage","orcid":null,"position":2,"is_corresponding":false},{"id":1377786,"name":"Cijun Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1377787,"name":"Warren F Kincaid","orcid":null,"position":4,"is_corresponding":false},{"id":1377173,"name":"Adrian Ford","orcid":"0000-0002-2901-7346","position":5,"is_corresponding":false},{"id":1377788,"name":"Luke G. Westbrook","orcid":null,"position":6,"is_corresponding":false},{"id":1377789,"name":"Seth D. Brown","orcid":null,"position":7,"is_corresponding":false},{"id":1377790,"name":"Tatum DeMarco","orcid":null,"position":8,"is_corresponding":false},{"id":506101,"name":"James L. Hougland","orcid":"0000-0003-0444-1017","position":9,"is_corresponding":false},{"id":483470,"name":"John M. Franck","orcid":"0000-0002-5432-4823","position":10,"is_corresponding":false},{"id":1377174,"name":"Xiaoran Hu","orcid":"0000-0001-7598-4516","position":11,"is_corresponding":false},{"id":1377171,"name":"Xuancheng Fu","orcid":"0000-0002-3402-943X","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T02:48:29.165853Z","pmid":"41089441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}