{"doi":"10.1039/d5sc02528a","title":"Multifunctional chiral silanol ligands for enantioselective catalysis","abstract":"We report transition metal catalysis using novel chiral metal-chelating ligands featuring a silanol coordinating group and peptide-like aminoamide scaffold. The catalytic properties of the silanol ligand are demonstrated through an enantioselective Cu-catalyzed N-H insertion affording unnatural amino acid derivatives in high selectivity. Our investigations into the silanol coordination mode include DFT calculations, ligand structure investigations, and X-ray structure analyses, which support the formation of an H-bond stabilized silanol-chelating copper carbenoid complex. A π-π stacking interaction revealed by DFT calculations is proposed to enable selectivity for aryl diazoacetate substrates, overcoming some of the traditional limitations of using these substrates.","journal":"Chemical Science","year":2025,"id":553159,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1336533,"name":"Kevin Blanco-Herrero","orcid":"0009-0000-0646-3493","position":1,"is_corresponding":false},{"id":1055469,"name":"Turki M. Alturaifi","orcid":"0000-0002-6379-1669","position":2,"is_corresponding":false},{"id":452547,"name":"James C. Fettinger","orcid":"0000-0002-6428-4909","position":3,"is_corresponding":false},{"id":285942,"name":"Peng Liu","orcid":"0000-0002-8188-632X","position":4,"is_corresponding":false},{"id":1336534,"name":"Annaliese K. Franz","orcid":"0000-0002-4841-2448","position":5,"is_corresponding":false},{"id":1336532,"name":"Yun‐Pu Chang","orcid":"0000-0003-2866-1735","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T02:54:41.819682Z","pmid":"40611991","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}