{"doi":"10.1039/d5sc00054h","title":"Access to arynes from arenes <i>via</i> net dehydrogenation: scope, synthetic applications and mechanistic analysis","abstract":"to generate arynes. (2) We developed a two-step process to convert arenes into aryl(Mes)iodonium salts and ultimately trapped arynes to expand the scope of compatible arenes. The net transformations from arenes to trapped arynes are complete with 2-4 hours. Mechanistic analysis through competition experiments, deuterium kinetic isotope effects (DKIE) and Density Functional Theory (DFT) provide key comparisons of the two approaches described in this work and yield a user's guide for selecting the appropriate \"onium\" leaving group based on the arene.","journal":"Chemical Science","year":2025,"id":517095,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1024893,"name":"Bryan E. Metze","orcid":null,"position":1,"is_corresponding":false},{"id":1338588,"name":"Nicole Javaly","orcid":null,"position":2,"is_corresponding":false},{"id":524186,"name":"Theresa M. McCormick","orcid":"0000-0003-1745-2911","position":3,"is_corresponding":false},{"id":719292,"name":"David R. Stuart","orcid":"0000-0003-3519-9067","position":4,"is_corresponding":false},{"id":1024259,"name":"Riley A. Roberts","orcid":"0000-0003-1733-2338","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T02:48:54.768083Z","pmid":"40018665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}