{"doi":"10.1039/d5nh00206k","title":"Pinocytosis inhibitory nanoparticles enhance aPD-1 antibody delivery and efficacy while avoiding toxicity in the treatment of solid tumors","abstract":"enhanced delivery of the small molecule actin inhibitor latrunculin A (LatA). This \"indirect targeting\" strategy is applied to improve anti-programmed death receptor 1 (aPD-1) antibody administration in mice bearing melanoma and colon carcinoma, decreasing aPD-1 interaction with the MPS, avoiding liver toxicity, increasing engagement with target cells, and modulating the immune microenvironment of solid tumors. The resulting change in biodistribution significantly improved safety, anticancer efficacy, and overall survival. Our methodology may be employed to enhance a wide range of monoclonal antibody therapies.","journal":"Nanoscale Horizons","year":2025,"id":544932,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1435825,"name":"Haeik Park","orcid":null,"position":1,"is_corresponding":false},{"id":326128,"name":"Wenan Qiang","orcid":"0000-0001-5068-7128","position":2,"is_corresponding":false},{"id":334977,"name":"Ge Lin","orcid":"0000-0002-4586-2603","position":3,"is_corresponding":false},{"id":1009755,"name":"Sultan Almunif","orcid":"0000-0002-9514-5549","position":4,"is_corresponding":false},{"id":681356,"name":"Swagat Sharma","orcid":"0000-0002-4829-594X","position":5,"is_corresponding":false},{"id":758294,"name":"Débora B. Scariot","orcid":"0000-0002-8681-0172","position":6,"is_corresponding":false},{"id":434145,"name":"Jie Lu","orcid":"0000-0002-6982-2294","position":7,"is_corresponding":false},{"id":1435826,"name":"R Reichert","orcid":null,"position":8,"is_corresponding":false},{"id":240963,"name":"Bin Zhang","orcid":"0000-0002-6631-7647","position":9,"is_corresponding":false},{"id":363601,"name":"Evan A. Scott","orcid":"0000-0002-8945-2892","position":10,"is_corresponding":false},{"id":1435824,"name":"Stephanie R. Zelenetz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40552380","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}