{"doi":"10.1039/d5lc00373c","title":"A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging","abstract":"while also providing a platform for clinically relevant interventions such as radiotherapy and positron emission tomography (PET) imaging. To simulate the heterogeneous oxygen distribution found in tumors, the ToC model incorporates an oxygen gradient achieved through a straightforward chemical oxygen scavenging system. A unique innovation of this device is the integration of a thin scintillator plate, which enables high-resolution radioluminescence microscopy imaging of tumor metabolism under hypoxia and normoxia conditions using clinically approved PET tracers such as fluorodeoxyglucose (FDG). The response of this hypoxic model to radiation therapy (10 Gy X-ray) demonstrated ∼4-fold higher radioresistance compared to the normoxic ToC model, as assessed by colony formation potential. Additionally, DNA damage observed in the normoxic ToC model was ∼5-fold higher than that in the hypoxic model. Furthermore, the metabolic consumption of glucose was found to mirror the localization of hypoxia, validating the use of this biomarker for planning radiation therapy. The integration of high-resolution radionuclide imaging within ToC models enables on-chip PET imaging and facilitates oncology research and discovery, offering innovative capabilities for the preclinical testing of novel cancer therapies in a clinically relevant environment.","journal":"Lab on a Chip","year":2025,"id":517571,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9056,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1383879,"name":"Myra Kurosu Jalil","orcid":"0000-0002-9363-4592","position":1,"is_corresponding":false},{"id":1384571,"name":"Veronica Ibanez Gaspar","orcid":null,"position":2,"is_corresponding":false},{"id":1383880,"name":"Andrea Sofia Flores Perez","orcid":"0009-0008-0137-9821","position":3,"is_corresponding":false},{"id":576009,"name":"Hieu T. M. Nguyen","orcid":"0000-0003-2094-4773","position":4,"is_corresponding":false},{"id":561712,"name":"Syamantak Khan","orcid":"0000-0002-5864-1842","position":5,"is_corresponding":false},{"id":469531,"name":"Sindy K. Y. Tang","orcid":"0000-0003-1465-2432","position":6,"is_corresponding":false},{"id":354461,"name":"Yunzhi Yang","orcid":"0000-0002-3891-0574","position":7,"is_corresponding":false},{"id":301440,"name":"Guillem Pratx","orcid":"0000-0002-0247-6470","position":8,"is_corresponding":false},{"id":242296,"name":"Rohollah Nasiri","orcid":"0000-0002-8245-692X","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"40762641","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}